Wang Meichen, Phillips Timothy D
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Toxicol Environ Health Sci. 2020 Dec;12(4):355-361. doi: 10.1007/s13530-020-00058-2. Epub 2020 Jun 3.
Polychlorinated biphenyls (PCBs) are lipophilic and persistent environmental pollutants that are readily absorbed and accumulated in high concentrations in fatty tissues of humans and animals. Invertebrate animals, such as oysters, are vulnerable and sensitive to PCB contamination.
Previously, our in vitro isothermal studies have shown that acid processed montmorillonites (APM) can effectively bind PCBs and Aroclors. Therefore, in a novel application of this work, a dietary strategy for shellfish was developed using APM, and its parent clay to reduce exposures to PCBs in oysters. PCB residues in oysters with clay treatment at different dietary inclusion rates and durations were measured and compared to a washout treatment.
The efficacy and safety of this strategy were supported by a significant reduction of PCB residues with the inclusion of a low level of APM (0.05%) during a 4-day treatment. Moreover, this sorbent strategy reduced PCB residues in oysters in a dose- and time-dependent manner.
Based on our results, it is possible that clay-based sorbents such as APM, can be included in the diet to significantly reduce exposures to PCBs.
多氯联苯（PCBs）是亲脂性且持久性的环境污染物，很容易被人体和动物的脂肪组织吸收并高浓度蓄积。诸如牡蛎之类的无脊椎动物对多氯联苯污染敏感且易受影响。
此前，我们的体外等温研究表明，酸处理蒙脱石（APM）能够有效结合多氯联苯和氯丹。因此，在这项工作的一项新应用中，开发了一种使用酸处理蒙脱石及其母黏土的贝类饮食策略，以减少牡蛎对多氯联苯的接触。测量了不同饮食添加率和持续时间下经黏土处理的牡蛎中的多氯联苯残留量，并与洗脱处理进行比较。
在为期4天的处理过程中，添加低水平的酸处理蒙脱石（0.05%）可显著降低多氯联苯残留量，这支持了该策略的有效性和安全性。此外，这种吸附剂策略以剂量和时间依赖的方式降低了牡蛎中的多氯联苯残留量。
根据我们的研究结果，有可能在饮食中添加诸如酸处理蒙脱石之类的黏土基吸附剂，以显著减少对多氯联苯的接触。
