College of Veterinary Medicine Mississippi State University Mississippi State MS USA.
Department of Agricultural and Biological Engineering Mississippi State University Mississippi State MS USA.
Animal Model Exp Med. 2021 Jan 13;4(1):59-70. doi: 10.1002/ame2.12149. eCollection 2021 Mar.
Infection of bone tissue, or osteomyelitis, has become a growing concern in modern healthcare due in no small part to a rise in antibiotic resistance among bacteria, notably . The current standard of care involves aggressive, prolonged antibiotic therapy combined with surgical debridement of infected tissues. While this treatment may be sufficient for resolving a portion of cases, recurrences of the infection and associated risks including toxicity with long-term antibiotic usage have been reported. Therefore, there exists a need to produce safer, more efficacious options of treatment for osteomyelitis. In order to test treatment regimens, animal models that closely mimic the clinical condition and allow for accurate evaluation of therapeutics are necessary. Establishing a model that replicates features of osteomyelitis in humans continues to be a challenge to scientists, as there are many variables involved, including choosing an appropriate species and method to establish infection. This review addresses the refinement of animal models of osteomyelitis to reflect the clinical disease and test prospective therapeutics. The aim of this review is to explore studies regarding the use of animals for osteomyelitis therapeutics research and encourage further development of such animal models for the translation of results from the animal experiment to human medicine.
骨组织感染，即骨髓炎，已成为现代医疗保健中日益令人关注的问题，这在很大程度上要归因于细菌对抗生素的耐药性不断上升，尤其是 。目前的治疗标准包括积极、长期的抗生素治疗，并结合感染组织的手术清创。虽然这种治疗方法可能足以解决一部分病例，但感染的复发以及与长期使用抗生素相关的毒性等风险已被报道。因此，有必要为骨髓炎提供更安全、更有效的治疗选择。为了测试治疗方案，需要使用能够非常接近临床状况并能准确评估治疗效果的动物模型。科学家们一直在努力建立一种能够复制人类骨髓炎特征的模型，因为其中涉及许多变量，包括选择合适的物种和建立感染的方法。这篇综述讨论了对骨髓炎动物模型的改进，以反映临床疾病并测试潜在的治疗方法。本文的目的是探讨关于动物在骨髓炎治疗研究中的应用的研究，并鼓励进一步开发此类动物模型，以便将动物实验的结果转化为人类医学。
