Department of Pathology, Guangdong Medical University, No.1 Xincheng Road, Dongguan, 523808, Guangdong Province, China.
School of Public Health, Guangdong Medical University, Dongguan, 523808, Guangdong Province, China.
Med Oncol. 2021 Mar 18;38(4):43. doi: 10.1007/s12032-021-01488-9.
The incidence and mortality of colorectal cancer (CRC) have always been among the highest in the world, although the diagnosis and treatment are becoming more and more advanced. At present, the main reason is that patients have acquired drug resistance after long-term conventional drug treatment. An increasing number of evidences confirm the existence of cancer stem cells (CSCs), which are a group of special cells in cancer, only a small part of cancer cells. These special cell populations are not eliminated by chemotherapeutic drugs and result in tumor recurrence and metastasis after drug treatment. CSCs have the ability of self-renewal and multidirectional differentiation, which is associated with the occurrence and development of cancer. CSCs can be screened and identified by related surface markers. In this paper, the characteristic surface markers of CSCs in CRC and the related mechanism of drug resistance will be discussed in detail. A better understanding of the mechanism of CSCs resistance to chemotherapy may lead to better targeted therapy.
结直肠癌（CRC）的发病率和死亡率一直位居世界前列，尽管其诊断和治疗方法越来越先进。目前，主要原因是患者在长期常规药物治疗后产生了耐药性。越来越多的证据证实了癌症干细胞（CSC）的存在，CSC 是癌症中一组特殊的细胞，仅占癌症细胞的一小部分。这些特殊的细胞群不会被化疗药物消除，导致药物治疗后肿瘤复发和转移。CSC 具有自我更新和多向分化的能力，与癌症的发生和发展有关。可以通过相关的表面标记物来筛选和鉴定 CSC。本文将详细讨论 CRC 中 CSC 的特征表面标记物及其相关耐药机制。更好地了解 CSC 对化疗的耐药机制可能会导致更好的靶向治疗。
