藻类磁氧化镍纳米催化剂在加速吡啶并嘧啶衍生物合成中的应用。

Algal magnetic nickel oxide nanocatalyst in accelerated synthesis of pyridopyrimidine derivatives.

机构信息

Department of Marine Chemistry, Khorramshahr University of Marine Science and Technology, P.O. Box 669, Khorramshahr, Iran.

Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran.

出版信息

Sci Rep. 2021 Mar 18;11(1):6296. doi: 10.1038/s41598-021-85832-z.

This research presents a novel biological route for the biosynthesis of nickel oxide nanoparticles (NiO NPs) using marine macroalgae extract as a reducing and coating agent under optimized synthesis conditions. XRD and TEM analyses revealed that phytosynthesized NiO NPs are crystalline in nature with a spherical shape having a mean particle size of 32.64 nm. TGA results indicated the presence of marine-derived organic constituents on the surface of NiO NPs. It is found that biogenic NiO NPs with BET surface area of 45.59 mg is a highly efficient catalyst for benign one-pot preparation of pyridopyrimidine derivatives using aqueous reaction conditions. This environmentally friendly procedure takes considerable advantages of shorter reaction times, excellent product yields (up to 96%), magnetically viable nanocatalyst (7 runs), low catalyst loadings, and free toxic chemical reagents.

本研究提出了一种新颖的生物合成路线，使用海洋大型藻类提取物作为还原剂和包覆剂，在优化的合成条件下合成氧化镍纳米粒子（NiO NPs）。XRD 和 TEM 分析表明，所合成的 NiO NPs 为结晶性，具有球形形貌，平均粒径为 32.64nm。TGA 结果表明，NiO NPs 表面存在海洋衍生的有机成分。研究发现，生物合成的 NiO NPs 具有 BET 比表面积 45.59mg，是一种高效的催化剂，可在水相反应条件下温和地一锅法制备吡啶并嘧啶衍生物。该绿色环保方法具有反应时间短、产率高（高达 96%）、可回收利用的磁性纳米催化剂（7 次循环）、低催化剂用量和无毒性化学试剂等优点。