University of California, San Diego, CA.
Menopause. 2021 Mar 11;28(5):576-578. doi: 10.1097/GME.0000000000001735.
Bioidentical hormones have the exact same chemical and molecular structure as hormones that are produced in the human body. Bioidentical hormones are available as FDA-approved hormone formulations. Nonapproved custom-compounded preparations are marketed as bioidentical, but content is uncertain. The widespread use of compounded bioidentical hormone therapy despite the lack of evidence to support its safety and efficacy is concerning. This Practice Pearl highlights the 2020 recommendations from the National Academies of Sciences, Engineering, and Medicine regarding the use of compounded bioidentical hormones.
生物等同激素具有与人体自身产生的激素完全相同的化学和分子结构。生物等同激素可作为经 FDA 批准的激素制剂使用。未经批准的定制混合制剂也被作为生物等同激素销售，但成分并不明确。尽管缺乏支持其安全性和有效性的证据，但复合生物等同激素疗法的广泛应用令人担忧。本实践要点强调了 2020 年美国国家科学院、工程院和医学研究所针对使用复合生物等同激素的建议。
