Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA.
Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
J Clin Endocrinol Metab. 2021 Aug 18;106(9):e3760-e3770. doi: 10.1210/clinem/dgab187.
Per- and polyfluoroalkyl substances (PFAS) may alter body composition by lowering anabolic hormones and increasing inflammation, but data are limited, particularly in adolescence when body composition is rapidly changing.
To evaluate associations of PFAS plasma concentrations in childhood with change in body composition through early adolescence.
A total of 537 children in the Boston-area Project Viva cohort participated in this study. We used multivariable linear regression and Bayesian kernel machine regression (BKMR) to examine associations of plasma concentrations of 6 PFAS, quantified by mass spectrometry, in mid-childhood (mean age, 7.9 years; 2007-2010) with change in body composition measured by dual-energy x-ray absorptiometry from mid-childhood to early adolescence (mean age, 13.1 years).
In single-PFAS linear regression models, children with higher concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorodecanoate (PFDA), and perfluorohexane sulfonate (PFHxS) had less accrual of lean mass (eg, -0.33 [95% CI: -0.52, -0.13] kg/m2 per doubling of PFOA). Children with higher PFOS and PFHxS had less accrual of total and truncal fat mass (eg, -0.32 [95% CI: -0.54, -0.11] kg/m2 total fat mass per doubling of PFOS), particularly subcutaneous fat mass (eg, -17.26 [95% CI -32.25, -2.27] g/m2 per doubling of PFOS). Children with higher PFDA and perfluorononanoate (PFNA) had greater accrual of visceral fat mass (eg, 0.44 [95% CI: 0.13, 0.75] g/m2 per doubling of PFDA). Results from BKMR mixture models were consistent with linear regression analyses.
Early life exposure to some but not all PFAS may be associated with adverse changes in body composition.
全氟和多氟烷基物质（PFAS）可能通过降低合成代谢激素和增加炎症来改变身体成分，但数据有限，特别是在身体成分快速变化的青春期。
评估儿童时期 PFAS 血浆浓度与青春期前身体成分变化的关联。
波士顿地区项目活力队列中的 537 名儿童参与了这项研究。我们使用多变量线性回归和贝叶斯核机器回归（BKMR）来研究通过质谱法定量的 6 种 PFAS 在儿童中期（平均年龄 7.9 岁；2007-2010 年）的血浆浓度与青春期前（平均年龄 13.1 岁）通过双能 X 射线吸收法测量的身体成分变化之间的关联。
在单一 PFAS 线性回归模型中，具有较高浓度的全氟辛烷酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟癸酸（PFDA）和全氟己烷磺酸（PFHxS）的儿童，其瘦体重增加较少（例如，PFOA 浓度每增加一倍，瘦体重增加减少 0.33 [95%CI：-0.52，-0.13]kg/m2）。具有较高 PFOS 和 PFHxS 浓度的儿童，其总脂肪和躯干脂肪量的增加较少（例如，PFOS 浓度每增加一倍，总脂肪量增加减少 0.32 [95%CI：-0.54，-0.11]kg/m2），特别是皮下脂肪量（例如，PFOS 浓度每增加一倍，皮下脂肪量增加减少 17.26 [95%CI -32.25，-2.27]g/m2）。具有较高 PFDA 和全氟壬酸（PFNA）浓度的儿童，内脏脂肪量的增加较多（例如，PFDA 浓度每增加一倍，内脏脂肪量增加 0.44 [95%CI：0.13，0.75]g/m2）。混合模型的 BKMR 结果与线性回归分析一致。
生命早期接触某些但不是所有的 PFAS 可能与身体成分的不利变化有关。
