史诗盟友：一款用于改善男男性行为者 HIV 护理和抗逆转录病毒依从性的游戏化移动应用程序。
Epic Allies: A Gamified Mobile App to Improve Engagement in HIV Care and Antiretroviral Adherence among Young Men Who have Sex with Men.
机构信息
Institute for Global Health and Infectious Diseases, University of North Carolina, 130 Mason Farm Road, CB# 7030, Chapel Hill, NC, 27599, USA.
Gillings School of Global Public Health, Department of Health Behavior, University of North Carolina, Chapel Hill, NC, USA.
出版信息
AIDS Behav. 2021 Aug;25(8):2599-2617. doi: 10.1007/s10461-021-03222-y. Epub 2021 Mar 19.
Abstract
HIV incidence among young men who have sex with men (YMSM) is disproportionally high. Youth living with HIV demonstrate low rates of sustained virologic suppression (VS). Epic Allies, a theory-based behavioral intervention mobile app, utilizes self-management tools, gamification, and social support to improve engagement in care and antiretroviral adherence among YMSM living with HIV. A two-arm individually randomized-controlled trial enrolled 146 participants aged 16 to 24 years old to test the efficacy of Epic Allies to achieve VS. Both study arms showed improved VS at 26-weeks (62.9% intervention; 73.5% control; ARR = 0.93 (95% CI 0.73, 1.18)) and antiretroviral adherence; intervention effects were amplified in regular app users. Issues with recruitment and app usage metrics limit the ability to definitively say that the app was effective in causing behavior changes resulting in improved health outcomes. (ClinicalTrials.gov Identifier: NCT02782130).
摘要
男男性行为者（MSM）中的 HIV 发病率不成比例地高。感染 HIV 的年轻人持续病毒抑制（VS）的比例很低。基于理论的行为干预移动应用程序“Epic Allies”利用自我管理工具、游戏化和社会支持，提高了 HIV 感染者的护理参与度和抗逆转录病毒治疗的依从性。一项双臂、个体随机对照试验招募了 146 名年龄在 16 至 24 岁的参与者，以测试 Epic Allies 实现 VS 的效果。两个研究组在 26 周时的 VS 均得到改善（干预组为 62.9%，对照组为 73.5%；ARR=0.93（95%CI 0.73, 1.18））和抗逆转录病毒治疗的依从性；在经常使用应用程序的用户中，干预效果得到了放大。招募问题和应用程序使用指标限制了明确表示该应用程序能够有效促使行为发生改变，从而改善健康结果的能力。（ClinicalTrials.gov 标识符：NCT02782130）
相似文献
1
Epic Allies: A Gamified Mobile App to Improve Engagement in HIV Care and Antiretroviral Adherence among Young Men Who have Sex with Men.史诗盟友：一款用于改善男男性行为者 HIV 护理和抗逆转录病毒依从性的游戏化移动应用程序。
AIDS Behav. 2021 Aug;25(8):2599-2617. doi: 10.1007/s10461-021-03222-y. Epub 2021 Mar 19.
2
Epic Allies, a Gamified Mobile Phone App to Improve Engagement in Care, Antiretroviral Uptake, and Adherence Among Young Men Who Have Sex With Men and Young Transgender Women Who Have Sex With Men: Protocol for a Randomized Controlled Trial.Epic Allies，一款用于提高男男性行为者和男男性行为的年轻跨性别女性参与护理、抗逆转录病毒药物服用及依从性的游戏化手机应用程序：一项随机对照试验方案
JMIR Res Protoc. 2018 Apr 5;7(4):e94. doi: 10.2196/resprot.8811.
3
Adaptation of a Theory-Based Social Networking and Gamified App-Based Intervention to Improve Pre-Exposure Prophylaxis Adherence Among Young Men Who Have Sex With Men in Bangkok, Thailand: Qualitative Study.基于理论的社交网络和游戏化应用程序干预措施在泰国曼谷改善男男性行为者的暴露前预防药物依从性的适应性：定性研究。
J Med Internet Res. 2021 Nov 4;23(11):e23852. doi: 10.2196/23852.
4
A Mobile Phone App to Support Adherence to Daily HIV Pre-exposure Prophylaxis Engagement Among Young Men Who Have Sex With Men and Transgender Women Aged 15 to 19 Years in Thailand: Pilot Randomized Controlled Trial.一款手机应用程序支持每日艾滋病毒暴露前预防用药坚持使用：在泰国，年龄在 15 至 19 岁的男男性行为者和跨性别女性中的一项试点随机对照试验。
JMIR Mhealth Uhealth. 2022 Apr 21;10(4):e25561. doi: 10.2196/25561.
5
Uptake of an App-Based Case Management Service for HIV-Positive Men Who Have Sex With Men in China: Process Evaluation Study.基于应用程序的 HIV 阳性男男性行为者病例管理服务在中国的采用情况：过程评估研究。
J Med Internet Res. 2023 Apr 26;25:e40176. doi: 10.2196/40176.
6
A Gamified Smartphone App to Support Engagement in Care and Medication Adherence for HIV-Positive Young Men Who Have Sex With Men (AllyQuest): Development and Pilot Study.一款用于支持男同性恋HIV感染者参与护理和坚持服药的游戏化智能手机应用程序（AllyQuest）：开发与试点研究。
JMIR Public Health Surveill. 2018 Apr 30;4(2):e34. doi: 10.2196/publichealth.8923.
7
A randomized controlled trial of an mHealth intervention for increasing access to HIV testing and care among young cisgender men and transgender women: the mLab App study protocol.一项 mHealth 干预措施增加 cisgender 男性和跨性别女性获得 HIV 检测和护理机会的随机对照试验：mLab App 研究方案。
BMC Public Health. 2021 Oct 29;21(1):1959. doi: 10.1186/s12889-021-12015-w.
8
Evaluation of smartphone APP-based case-management services among antiretroviral treatment-naïve HIV-positive men who have sex with men: a randomized controlled trial protocol.基于智能手机应用的个案管理服务在初治 HIV 阳性男男性行为者中的评估：一项随机对照试验方案。
BMC Public Health. 2020 Jan 20;20(1):85. doi: 10.1186/s12889-020-8171-5.
9
A Pilot Study of a Mobile App to Support HIV Antiretroviral Therapy Adherence Among Men Who Have Sex with Men Who Use Stimulants.一款用于支持男性同性性行为者中使用兴奋剂的男性接受 HIV 抗逆转录病毒治疗的依从性的移动应用程序的初步研究。
AIDS Behav. 2019 Nov;23(11):3184-3198. doi: 10.1007/s10461-019-02597-3.
10
Examining the Information Systems Success (ISS) of a mobile sexual health app (MyPEEPS Mobile) from the perspective of very young men who have sex with men (YMSM).从与男性发生性关系的非常年轻男性（YMSM）的角度审视移动性健康应用程序（MyPEEPS Mobile）的信息系统成功（ISS）。
Int J Med Inform. 2021 Sep;153:104529. doi: 10.1016/j.ijmedinf.2021.104529. Epub 2021 Jul 22.
引用本文的文献
1
Preliminary evaluation of a gamified smartphone intervention (O2O-PEP) for enhancing HIV post-exposure prophylaxis uptake in men who have sex with men: pilot feasibility study.一项用于提高男男性行为者艾滋病毒暴露后预防措施使用率的游戏化智能手机干预措施（线上到线下暴露后预防）的初步评估：试点可行性研究
BMC Public Health. 2025 Apr 25;25(1):1539. doi: 10.1186/s12889-025-22818-w.
2
The role of digital tools in enhancing antiretroviral therapy adherence among adolescents and young adults with HIV: a systematic review of randomized controlled trials.数字工具在提高感染艾滋病毒的青少年和青年抗逆转录病毒治疗依从性方面的作用：随机对照试验的系统评价
BMC Infect Dis. 2025 Mar 13;25(1):353. doi: 10.1186/s12879-025-10724-w.
3
Using a mobile application for antiretroviral therapy adherence in people living with HIV: A longitudinal pilot study.使用移动应用程序提高艾滋病毒感染者抗逆转录病毒疗法的依从性：一项纵向试点研究。
South Afr J HIV Med. 2025 Jan 31;26(1):1646. doi: 10.4102/sajhivmed.v26i1.1646. eCollection 2025.
4
Enhancing HIV Cognitive Abilities and Self-Management Through Information Technology-Assisted Interventions: Scoping Review.通过信息技术辅助干预增强HIV认知能力和自我管理：范围综述
J Med Internet Res. 2025 Jan 13;27:e57363. doi: 10.2196/57363.
5
A Web-Based Antiretroviral Therapy Adherence Intervention (Thrive With Me) in a Community-Recruited Sample of Sexual Minority Men Living With HIV: Results of a Randomized Controlled Study.基于网络的抗逆转录病毒治疗依从性干预（与我一起茁壮成长）在社区招募的 HIV 阳性性少数男性人群中的应用：一项随机对照研究的结果。
J Med Internet Res. 2024 Sep 30;26:e53819. doi: 10.2196/53819.
6
User Engagement With mHealth Interventions to Promote Treatment Adherence and Self-Management in People With Chronic Health Conditions: Systematic Review.用户对移动医疗干预措施的参与度，以促进慢性病患者的治疗依从性和自我管理：系统评价。
J Med Internet Res. 2024 Sep 24;26:e50508. doi: 10.2196/50508.
7
Systematic review and meta-analysis of interventions to promote medication adherence among children, adolescents, and young adults with medical conditions.对促进患有疾病的儿童、青少年和青年药物依从性干预措施的系统评价和荟萃分析。
J Pediatr Psychol. 2024 Jun 21. doi: 10.1093/jpepsy/jsae036.
8
A Pilot Randomized Controlled Trial of an mHealth Intervention to Improve PrEP Adherence Among Young Sexual Minority Men.一项改善年轻性少数男性人群中 PrEP 依从性的移动医疗干预措施的初步随机对照试验。
AIDS Behav. 2024 Aug;28(8):2804-2820. doi: 10.1007/s10461-024-04374-3. Epub 2024 May 31.
9
mHealth-Based Gamification Interventions Among Men Who Have Sex With Men in the HIV Prevention and Care Continuum: Systematic Review and Meta-Analysis.基于移动健康的游戏化干预在男男性行为者的 HIV 预防和护理连续体中的应用：系统评价和荟萃分析。
JMIR Mhealth Uhealth. 2024 Apr 15;12:e49509. doi: 10.2196/49509.
10
Patterns of engagement in digital mental health intervention for LGBTQ+ youth: a latent profile analysis.LGBTQ+青年参与数字心理健康干预的模式：一项潜在剖面分析
Front Digit Health. 2023 Nov 23;5:1254929. doi: 10.3389/fdgth.2023.1254929. eCollection 2023.
本文引用的文献
1
Research Priorities to End the Adolescent HIV Epidemic in the United States: Viewpoint.美国终结青少年艾滋病流行的研究重点：观点
JMIR Res Protoc. 2021 Jan 4;10(1):e22279. doi: 10.2196/22279.
2
Engagement in mHealth behavioral interventions for HIV prevention and care: making sense of the metrics.参与用于艾滋病毒预防和护理的移动健康行为干预措施：理解相关指标
Mhealth. 2020 Jan 5;6:7. doi: 10.21037/mhealth.2019.10.01. eCollection 2020.
3
Predictors of Condomless Anal Intercourse in Young HIV-Positive Men Who Have Sex With Men With Detectable Viral Loads.HIV 阳性的男男性行为者中，病毒载量可检测到的年轻人群发生无保护肛交的预测因素。
J Adolesc Health. 2020 Jun;66(6):672-683. doi: 10.1016/j.jadohealth.2019.12.006. Epub 2020 Jan 25.
4
Nonadherence and unsuppressed viral load across adolescence among US youth with perinatally acquired HIV.美国青少年艾滋病病毒母婴传播患者在青春期的不遵医行为和病毒载量未受抑制情况。
AIDS. 2019 Oct 1;33(12):1923-1934. doi: 10.1097/QAD.0000000000002301.
5
A CACE for assessing non-compliance: Addressing non-compliance in randomised controlled trials.一种评估不依从性的CACE：解决随机对照试验中的不依从性问题。
BJOG. 2019 Dec;126(13):1558-1559. doi: 10.1111/1471-0528.15506. Epub 2019 Jun 21.
6
Improving the Youth HIV Prevention and Care Continuums: The Adolescent Medicine Trials Network for HIV/AIDS Interventions.改善青少年艾滋病毒预防与护理连续服务：青少年医学艾滋病毒/艾滋病干预试验网络
JMIR Res Protoc. 2019 Mar 26;8(3):e12050. doi: 10.2196/12050.
7
Longitudinal Analysis of Syndemic Psychosocial Problems Predicting HIV Risk Behavior Among a Multicity Prospective Cohort of Sexually Active Young Transgender Women in the United States.美国多城市性活跃年轻跨性别女性前瞻性队列中，预测 HIV 风险行为的综合征心理社会问题的纵向分析。
J Acquir Immune Defic Syndr. 2019 Jun 1;81(2):184-192. doi: 10.1097/QAI.0000000000002009.
8
A Randomized Trial of an Online Risk Reduction Intervention for Young Black MSM.一项针对年轻黑人男男性行为者的在线风险降低干预的随机试验。
AIDS Behav. 2019 May;23(5):1166-1177. doi: 10.1007/s10461-018-2289-9.
9
eHealth to Enhance Treatment Adherence Among Youth Living with HIV.电子健康增进感染艾滋病毒青年的治疗依从性。
Curr HIV/AIDS Rep. 2018 Aug;15(4):336-349. doi: 10.1007/s11904-018-0407-y.
10
Epic Allies, a Gamified Mobile Phone App to Improve Engagement in Care, Antiretroviral Uptake, and Adherence Among Young Men Who Have Sex With Men and Young Transgender Women Who Have Sex With Men: Protocol for a Randomized Controlled Trial.Epic Allies，一款用于提高男男性行为者和男男性行为的年轻跨性别女性参与护理、抗逆转录病毒药物服用及依从性的游戏化手机应用程序：一项随机对照试验方案
JMIR Res Protoc. 2018 Apr 5;7(4):e94. doi: 10.2196/resprot.8811.
Zotero 插件