Institute for Global Health and Infectious Diseases, University of North Carolina, 130 Mason Farm Road, CB# 7030, Chapel Hill, NC, 27599, USA.
Gillings School of Global Public Health, Department of Health Behavior, University of North Carolina, Chapel Hill, NC, USA.
AIDS Behav. 2021 Aug;25(8):2599-2617. doi: 10.1007/s10461-021-03222-y. Epub 2021 Mar 19.
HIV incidence among young men who have sex with men (YMSM) is disproportionally high. Youth living with HIV demonstrate low rates of sustained virologic suppression (VS). Epic Allies, a theory-based behavioral intervention mobile app, utilizes self-management tools, gamification, and social support to improve engagement in care and antiretroviral adherence among YMSM living with HIV. A two-arm individually randomized-controlled trial enrolled 146 participants aged 16 to 24 years old to test the efficacy of Epic Allies to achieve VS. Both study arms showed improved VS at 26-weeks (62.9% intervention; 73.5% control; ARR = 0.93 (95% CI 0.73, 1.18)) and antiretroviral adherence; intervention effects were amplified in regular app users. Issues with recruitment and app usage metrics limit the ability to definitively say that the app was effective in causing behavior changes resulting in improved health outcomes. (ClinicalTrials.gov Identifier: NCT02782130).
男男性行为者（MSM）中的 HIV 发病率不成比例地高。感染 HIV 的年轻人持续病毒抑制（VS）的比例很低。基于理论的行为干预移动应用程序“Epic Allies”利用自我管理工具、游戏化和社会支持，提高了 HIV 感染者的护理参与度和抗逆转录病毒治疗的依从性。一项双臂、个体随机对照试验招募了 146 名年龄在 16 至 24 岁的参与者，以测试 Epic Allies 实现 VS 的效果。两个研究组在 26 周时的 VS 均得到改善（干预组为 62.9%，对照组为 73.5%；ARR=0.93（95%CI 0.73, 1.18））和抗逆转录病毒治疗的依从性；在经常使用应用程序的用户中，干预效果得到了放大。招募问题和应用程序使用指标限制了明确表示该应用程序能够有效促使行为发生改变，从而改善健康结果的能力。（ClinicalTrials.gov 标识符：NCT02782130）
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