Martusevich A K, Karuzin K A
Privolzhsky Research Medical University, 603155, Nizhny Novgorod, Russian Federation.
Association of Russian Ozone Therapy, 603089, Nizhny Novgorod, Russian Federation.
Vopr Pitan. 2021;90(1):94-101. doi: 10.33029/0042-8833-2021-90-1-94-101. Epub 2021 Jan 20.
In professional athletes who adapt to intense physical training and psycho-emotional stress, the formation of oxidative stress is shown. This fact determines the expediency of targeted correction of disorders of the balance of pro- and antioxidant systems in blood and tissues caused by intense physical training. of the work was to study the effect of vitamin-mineral complex on the parameters of oxidative blood metabolism in professional athletes. . The prospective study included 74 professional athletes representing cyclic sports and randomized into 2 groups: the main group (n=42), who personalized received one of two vitamin-mineral complexes (with different concentrations of antioxidants), and a control group (n=32), who received a placebo. The duration of the course of daily intake of vitamin-mineral complex, an additional source of vitamins C, E, A, D, group B, minerals and trace elements, a source of β-carotene (1.5 mg), lutein (4.5 mg) and L-carnitine, was 30 days. The parameters of oxidative metabolism of blood (the level of 8-isoprostan, oxidized low-density lipoproteins, superoxide dismutase activity, the concentration of carotenes, tocopherols, lycopene, lutein and zeaxanthin) were studied in the athletes of both groups before and after the course of intake, and in the main group these results were used to individualize the metabolic correction. . After completing the course of metabolic support, an increase in the concentration of lutein and zeaxanthin (1.26 fold), α- and β-carotene (1.21 and 1.17 fold, respectively), α- and γ-tocopherol (1.46 and 1.62 fold), and the coefficient vitamin E/cholesterol (1.18 fold) have been demonstrated in athletes. In addition, activation of superoxide dismutase (1.24 fold) and a decrease in the level of 8-isoprostane (1.49 fold) have been recorded. No such changes have been observed in the athletes included in the control group. . It was found that the course of metabolic support, including the use of individually prescribed vitamin-mineral complex, allowed to optimize the state of oxidative metabolism of athletes blood plasma.
在适应高强度体育训练和心理-情绪压力的职业运动员中，已显示出氧化应激的形成。这一事实决定了针对性纠正由高强度体育训练引起的血液和组织中促氧化剂和抗氧化剂系统平衡紊乱的合理性。本研究的目的是研究维生素-矿物质复合物对职业运动员血液氧化代谢参数的影响。前瞻性研究纳入了74名从事周期性运动的职业运动员，并随机分为2组：主要组（n = 42），个性化服用两种维生素-矿物质复合物之一（含不同浓度抗氧化剂），以及对照组（n = 32），服用安慰剂。作为维生素C、E、A、D、B族、矿物质和微量元素的额外来源，以及β-胡萝卜素（1.5毫克）、叶黄素（4.5毫克）和左旋肉碱来源的维生素-矿物质复合物的每日摄入疗程为30天。在两组运动员摄入疗程前后研究血液氧化代谢参数（8-异前列腺素水平、氧化型低密度脂蛋白、超氧化物歧化酶活性、胡萝卜素、生育酚、番茄红素、叶黄素和玉米黄质浓度），在主要组中，这些结果用于代谢纠正的个体化。在完成代谢支持疗程后，运动员体内叶黄素和玉米黄质浓度增加（1.26倍）、α-和β-胡萝卜素（分别为1.21和1.17倍）、α-和γ-生育酚（1.46和1.62倍）以及维生素E/胆固醇系数（1.18倍）。此外，还记录到超氧化物歧化酶的激活（1.24倍）和8-异前列腺素水平的降低（1.49倍）。对照组的运动员未观察到此类变化。研究发现，包括使用个体化规定的维生素-矿物质复合物在内的代谢支持疗程能够优化运动员血浆氧化代谢状态。
