Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Department of Endocrinology, Dalian Hospital affiliated to Shengjing Hospital of China Medical University, Shenyang, China.
Arch Endocrinol Metab. 2021 Nov 3;65(3):269-276. doi: 10.20945/2359-3997000000339. Epub 2021 Mar 19.
To investigate the association between plasma Hydrogen Sulfide (HS) levels and visceral fat area (VFA) among Chinese young men.
This cross-sectional study involved 156 Chinese male subjects, aged 18-45 years, who visited the First Hospital of Qinhuangdao (Hebei, China) in 2014 for annual health check-up. Participants were categorized into: low (VFA < 75.57 cm), medium (75.57 cm ≤ VFA<100.37 cm), and high (VFA ≥ 100.37 cm) (n = 52/group). We estimated VFA and plasma HS levels by using bioelectrical impedance analysis and a fluorescence probe-based approach, respectively. The associations of HS with VFA and obesity anthropometric measures were assessed.
In the high VFA group, the body mass index (BMI, 30.4 ± 2.45 kg/m), total body fat (TBF, 27.9 ± 3.23 kg), plasma HS (3.5 µmol/L), free fatty acid (FFA, 0.6 ± 0.24 mmol/L), triglyceride (TG, 2.0 mmol/L), and total cholesterol (TC, 5.5 ± 1.02 mmol/L) levels were significantly higher than that of those of the low and medium VFA groups, respectively ( < 0.05). Plasma HS levels were found to be inversely correlated with VFA, TBF, waist circumference, BMI, FFA, LnFINS, LnHOMA-IR, LnTG, TC, and LDL-C ( < 0.05). Multiple backward stepwise regression analysis revealed an inverse correlation of plasma HS levels with FFA (β = -0.214, = 0.005) and VFA (β = -0.429, < 0.001), independent of adiposity measures and other confounding factors.
VFA was independently and inversely associated with plasma HS levels among Chinese young men. Therefore, determining plasma HS levels could aid in the assessment of abnormal VAT distribution.
探讨中国年轻男性血浆硫化氢（HS）水平与内脏脂肪面积（VFA）的关系。
本横断面研究纳入了 2014 年在秦皇岛第一医院（河北）进行年度健康检查的 156 名年龄在 18-45 岁的中国男性。根据 VFA 将参与者分为三组：低（VFA<75.57cm）、中（75.57cm≤VFA<100.37cm）和高（VFA≥100.37cm）（每组 52 人）。使用生物电阻抗分析和基于荧光探针的方法分别估计 VFA 和血浆 HS 水平。评估 HS 与 VFA 和肥胖人体测量指标的相关性。
在高 VFA 组中，体重指数（BMI，30.4±2.45kg/m2）、总体脂肪（TBF，27.9±3.23kg）、血浆 HS（3.5μmol/L）、游离脂肪酸（FFA，0.6±0.24mmol/L）、甘油三酯（TG，2.0mmol/L）和总胆固醇（TC，5.5±1.02mmol/L）水平明显高于低 VFA 和中 VFA 组（<0.05）。血浆 HS 水平与 VFA、TBF、腰围、BMI、FFA、LnFINS、LnHOMA-IR、LnTG、TC 和 LDL-C 呈负相关（<0.05）。多元逐步回归分析显示，血浆 HS 水平与 FFA（β=-0.214，=0.005）和 VFA（β=-0.429，<0.001）呈负相关，独立于肥胖指标和其他混杂因素。
中国年轻男性的 VFA 与血浆 HS 水平独立且呈负相关。因此，测定血浆 HS 水平有助于评估异常 VAT 分布。
