Zhu Lin, Yang Bo, Ma Dongxia, Wang Lan, Duan Wu
Department of Pediatrics, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Jun 3;13:1873-1886. doi: 10.2147/DMSO.S249605. eCollection 2020.
Hydrogen sulfide (HS) is now increasingly considered to be the third gasotransmitter alongside other gaseous signaling molecules, nitric oxide (NO) and carbon monoxide (CO). HS is produced by a variety of endogenous enzymatic and non-enzymatic pathways and acts as a modulator of the physiological and pathological events of the body. Adipocytes express the cystathionine γ lyase (CSE)/HS system, which modulates a variety of biological activities in adipose tissue (AT), including inflammation, apoptosis, insulin resistance, adipokine secretion and adipocyte differentiation. Abnormalities in the physiological functions of AT play an important role in the process of diabetes mellitus. Therefore, this review provides an overview of the general aspects of HS biochemistry, the effect of HS on AT function and diabetes mellitus and its molecular signalling mechanisms as well as the potential application of HS in pharmacotherapy.
硫化氢（HS）如今越来越被视为与其他气体信号分子一氧化氮（NO）和一氧化碳（CO）并列的第三种气体递质。HS通过多种内源性酶促和非酶促途径产生，并作为身体生理和病理事件的调节剂。脂肪细胞表达胱硫醚γ裂解酶（CSE）/HS系统，该系统调节脂肪组织（AT）中的多种生物学活性，包括炎症、细胞凋亡、胰岛素抵抗、脂肪因子分泌和脂肪细胞分化。AT生理功能异常在糖尿病发生过程中起重要作用。因此，本综述概述了HS生物化学的一般方面、HS对AT功能和糖尿病的影响及其分子信号机制，以及HS在药物治疗中的潜在应用。
