Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Sho-goin, Sakyo-ku, Kyoto 606-8507, Japan.
Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Stem Cell Reports. 2021 Apr 13;16(4):997-1005. doi: 10.1016/j.stemcr.2021.02.014. Epub 2021 Mar 18.
The past decade has witnessed an extremely rapid increase in the number of newly established stem cell lines. However, due to the lack of a standardized format, data exchange among stem cell line resources has been challenging, and no system can search all stem cell lines across resources worldwide. To solve this problem, we have developed the Integrated Collection of Stem Cell Bank data (ICSCB) (http://icscb.stemcellinformatics.org/), the largest database search portal for stem cell line information, based on the standardized data items and terms of the MIACARM framework. Currently, ICSCB can retrieve >16,000 cell lines from four major data resources in Europe, Japan, and the United States. ICSCB is automatically updated to provide the latest cell line information, and its integrative search helps users collect cell line information for over 1,000 diseases, including many rare diseases worldwide, which has been a formidable task, thereby distinguishing itself from other database search portals.
过去十年中，新建立的干细胞系数量呈指数级增长。然而，由于缺乏标准化的格式，干细胞系资源之间的数据交换一直具有挑战性，并且没有系统可以搜索全球所有的干细胞系资源。为了解决这个问题，我们基于 MIACARM 框架的标准化数据项和术语，开发了集成的干细胞库数据集合（ICSCB）（http://icscb.stemcellinformatics.org/），这是最大的干细胞系信息数据库搜索门户。目前，ICSCB 可以从欧洲、日本和美国的四个主要数据资源中检索超过 16000 种细胞系。ICSCB 会自动更新，以提供最新的细胞系信息，其集成搜索有助于用户收集 1000 多种疾病的细胞系信息，包括全球许多罕见疾病，这是一项艰巨的任务，因此它有别于其他数据库搜索门户。
