Fraunhofer-Institute für Biomedizinische Technik (IBMT), Joseph-von-Fraunhofer Weg 1, 66280 Sulzbach, Germany.
Berlin Institute of Health Center for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Cells. 2023 Dec 1;12(23):2756. doi: 10.3390/cells12232756.
The European Bank for induced pluripotent Stem Cells (EBiSC) was established in 2014 as a non-profit project for the banking, quality control, and distribution of human iPSC lines for research around the world. EBiSC iPSCs are deposited from diverse laboratories internationally and, hence, a key activity for EBiSC is standardising not only the iPSC lines themselves but also the data associated with them. This includes enabling unique nomenclature for the cells, as well as applying uniformity to the data provided by the cell line generator versus quality control data generated by EBiSC, and providing mechanisms to share personal data in a secure and GDPR-compliant manner. A joint approach implemented by EBiSC and the human pluripotent stem cell registry (hPSCreg) has provided a solution that enabled hPSCreg to improve its registration platform for iPSCs and EBiSC to have a pipeline for the import, standardisation, storage, and management of data associated with EBiSC iPSCs. In this work, we describe the experience of cell line data management for iPSC banking throughout the course of EBiSC's development as a central European banking infrastructure and present a model for how this could be implemented by other iPSC repositories to increase the FAIRness of iPSC research globally.
欧洲诱导多能干细胞银行（EBiSC）成立于 2014 年，是一个非盈利项目，用于银行存储、质量控制和分发人类诱导多能干细胞系，以支持全球范围内的研究。EBiSC 的 iPS 细胞是从国际上不同的实验室中储存的，因此，EBiSC 的一个关键活动不仅是标准化 iPSC 系本身，还有与之相关的数据。这包括为细胞赋予独特的命名法，以及使细胞系生成器提供的数据与 EBiSC 生成的质量控制数据保持一致，并提供以安全且符合 GDPR 的方式共享个人数据的机制。EBiSC 和人类多能干细胞注册中心（hPSCreg）实施的联合方法提供了一个解决方案，使 hPSCreg 能够改进其 iPSC 注册平台，使 EBiSC 能够导入、标准化、存储和管理与 EBiSC iPSC 相关的数据。在这项工作中，我们描述了 EBiSC 作为一个中欧银行基础设施发展过程中 iPSC 银行的细胞系数据管理经验，并提出了一个模型，说明其他 iPSC 存储库如何实施这一模型，以提高全球 iPSC 研究的 FAIR 程度。
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