Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Ecotoxicol Environ Saf. 2021 Jun 1;215:112133. doi: 10.1016/j.ecoenv.2021.112133. Epub 2021 Mar 16.
Although short-term exposure to particulate matter (PM) was associated with increased glucocorticoids (GCs) levels, available evidence on associations of long-term exposure to PM and GCs levels is still scant. Previous studies has showed that meat intake is associated with sex hormones levels, but it is unknown whether meat intake is associated with GCs levels. Furthermore, the role of meat intake in the associations between PM and GCs levels remains unclear.
The aims of this study were to explore the associations of long-term exposure to PM and GCs levels among Chinese rural adults, and the role of meat intake in these associations.
A total of 6223 subjects were recruited from the Henan Rural Cohort Study. Serum GCs levels were measured with liquid chromatography-tandem mass spectrometry. The concentrations of PM (PM and PM) for each subject were assessed with machine learning algorithms. The food frequency questionnaire (FFQ) was used to obtain each participant' information on meat intake. The effects of PM and meat intake on GCs levels were assessed using generalized linear models. In addition, modification analyses were performed to identify the role of meat intake played in the associations of PM with serum GCs levels.
Per 1 μg/m increment in PM or PM concentration was associated with a 0.364 ng/ml (95% confidence interval (CI): 0.234, 0.494) or 0.227 ng/ml (95%CI: 0.110, 0.343) increase in serum cortisone, respectively. In addition, the moderation effects of total meat intake and red meat intake on the associations of long-term exposure to PM or PM with serum cortisone were observed (P < 0.05), indicating that individuals who had high levels of PM or PM and meat intake were more susceptible to have a higher state of serum cortisone.
Our findings suggested that long-term exposure to PM or PM was associated with serum cortisone. Moreover, meat intake was found to be a significant moderator in the association of PM or PM with serum cortisone levels.
尽管短期暴露于颗粒物（PM）与糖皮质激素（GCs）水平升高有关，但关于长期暴露于 PM 与 GCs 水平之间关联的证据仍然很少。先前的研究表明，肉类摄入量与性激素水平有关，但尚不清楚肉类摄入量是否与 GCs 水平有关。此外，肉类摄入量在 PM 与 GCs 水平之间的关联中的作用尚不清楚。
本研究旨在探讨中国农村成年人长期暴露于 PM 与 GCs 水平之间的关系，以及肉类摄入量在这些关系中的作用。
共招募了 6223 名来自河南农村队列研究的参与者。使用液相色谱-串联质谱法测量血清 GCs 水平。使用机器学习算法评估每个参与者的 PM（PM 和 PM）浓度。使用食物频率问卷（FFQ）获取每位参与者的肉类摄入量信息。使用广义线性模型评估 PM 和肉类摄入量对 GCs 水平的影响。此外，还进行了修饰分析，以确定肉类摄入量在 PM 与血清 GCs 水平之间的关联中的作用。
PM 或 PM 浓度每增加 1μg/m，血清皮质酮分别增加 0.364ng/ml（95%置信区间（CI）：0.234，0.494）或 0.227ng/ml（95%CI：0.110，0.343）。此外，总肉类摄入量和红色肉类摄入量对 PM 或 PM 与血清皮质酮之间关联的调节作用观察到（P<0.05），这表明 PM 或 PM 水平较高且肉类摄入量较高的个体更易出现较高的血清皮质酮状态。
我们的研究结果表明，长期暴露于 PM 或 PM 与血清皮质酮有关。此外，肉类摄入量被发现是 PM 或 PM 与血清皮质酮水平之间关联的重要调节剂。
