Smaha Juraj, Kužma Martin, Jackuliak Peter, Payer Juraj
Vnitr Lek. 2020 Winter;66(8):494-500.
The immunomodulatory effect of vitamin D and its potential in prevention and treatment of acute respiratory infections have long been of interest to many scientific teams around the world. Several meta-analyses in the last 10 years have confirmed the protective (albeit of modest size) effect of vitamin D against respiratory infections. Because of many overlapping risk factors for vitamin D deficiency and severe COVID-19 infection, many experts believe that vitamin D supplementation could play an important role in prevention and treatment of the new coronavirus disease. Based on available data on the immunological action of vitamin D, it is possible that vitamin D could modulate the bodys response to SARS-CoV-2 infection both in the early viraemic phase and in later hyperinflammatory phase typical for the severe course of the disease. The first available data from epidemiological studies suggest that low serum vitamin D levels are associated with increased susceptibility to the new coronavirus infection as well as with severe course of the disease.
维生素D的免疫调节作用及其在预防和治疗急性呼吸道感染方面的潜力长期以来一直为世界各地的许多科研团队所关注。过去十年的几项荟萃分析证实了维生素D对呼吸道感染具有保护作用（尽管作用程度不大）。由于维生素D缺乏和严重COVID-19感染存在许多重叠的风险因素，许多专家认为补充维生素D可能在新型冠状病毒病的预防和治疗中发挥重要作用。根据关于维生素D免疫作用的现有数据，维生素D有可能在疾病严重病程典型的早期病毒血症阶段和后期高炎症阶段调节机体对SARS-CoV-2感染的反应。流行病学研究的首批可用数据表明，血清维生素D水平低与新型冠状病毒感染易感性增加以及疾病严重病程相关。
