Griffiths S D, Cawley J C
University Department of Haematology, Royal Liverpool Hospital, U.K.
Leukemia. 1988 Jun;2(6):377-81.
Lymphokine-activated killer (LAK) cell activity generated from peripheral blood was tested in 6 patients with typical hairy cell leukemia, 3 not on treatment with alpha-interferon (alpha-IFN) and 3 receiving therapy. In all cases, substantial killing of the LAK-sensitive target Daudi was observed, but hairy cells, whether or not they had been pretreated with alpha-IFN, were uniformly resistant to LAK lysis. The hairy cells were also resistant to LAK cell killing generated from normal peripheral blood mononuclear cells. alpha-IFN added at various times during LAK generation had little or no effect on LAK activity. It is concluded that LAK cells are not important in mediating the beneficial effects of alpha-IFN in hairy cell leukemia.
对6例典型毛细胞白血病患者外周血产生的淋巴因子激活的杀伤（LAK）细胞活性进行了检测，其中3例未接受α干扰素（α-IFN）治疗，3例正在接受治疗。在所有病例中，均观察到对LAK敏感靶细胞Daudi有大量杀伤，但毛细胞无论是否用α-IFN预处理，均对LAK裂解具有一致的抗性。毛细胞对正常外周血单个核细胞产生的LAK细胞杀伤也具有抗性。在LAK产生过程中的不同时间添加α-IFN对LAK活性几乎没有影响。得出的结论是，LAK细胞在介导α-IFN对毛细胞白血病的有益作用中并不重要。
