Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, No. 1, Sec. 3, Chung-Hsiao East Rd., Taipei, 106, Taiwan.
Chemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Mikrochim Acta. 2021 Mar 19;188(4):131. doi: 10.1007/s00604-021-04768-3.
An electrocatalyst modified electrode has been investigated to develop the rapid detection of antibiotics. The modified electrocatalyst was intended for the determination of sulfadiazine (SFZ) in biological fluids by electrochemical methods. Nanocube of zinc manganite (ZnMnO-NC) is prepared by hydrothermal method and a glassy carbon electrode (GCE) has been modified with the zinc manganite. The ZnMnO/GCE exhibit enhanced detection performances towards SFZ drug owing to their selective adsorption ability and the combination of electrostatic attraction of nanocube with SFZ. The modified electrocatalyst shows excellent electrocatalytic interactions with antibiotic drug. Besides, the modified sensors exhibit nanomolar detection limit (0.0021 μM) in 0.05 M phosphate buffer (pH = 7.0) using differential pulse voltammetric method. The working range of the modified electrode is 0.008-1264 μM, and the sensitivity of the SFZ sensor is 11.44 μA μM cm. The modified sensor stability and reproducibility performances have been examined by electrochemical method. In addition, the obtained results of real sample analysis with different concentrations of SFZ in biological fluids are satisfactory with good recovery.
一种电化学催化剂修饰电极已被研究用于快速检测抗生素。修饰的电催化剂旨在通过电化学方法来测定生物流体中的磺胺嘧啶（SFZ）。采用水热法制备了锌锰矿纳米立方（ZnMnO-NC），并用玻璃碳电极（GCE）对其进行了修饰。ZnMnO/GCE 对 SFZ 药物表现出增强的检测性能，这归因于其选择性吸附能力以及纳米立方与 SFZ 之间的静电吸引的结合。修饰的电催化剂与抗生素药物表现出优异的电催化相互作用。此外，修饰后的传感器在 0.05 M 磷酸盐缓冲液（pH = 7.0）中使用差分脉冲伏安法检测 SFZ 的检测限低至纳摩尔级（0.0021 μM）。修饰电极的工作范围为 0.008-1264 μM，SFZ 传感器的灵敏度为 11.44 μA μM cm。通过电化学方法检查了修饰传感器的稳定性和重现性性能。此外，对生物流体中不同浓度的 SFZ 进行实际样品分析得到的结果令人满意，回收率良好。
