Lysle D T, Cunnick J E, Fowler H, Rabin B S
Division of Clinical Immunopathology, University of Pittsburgh, PA.
Life Sci. 1988;42(22):2185-94. doi: 10.1016/0024-3205(88)90369-4.
Recent research has indicated that physical stressors, such as electric shock, can suppress immune function in rats. The present study investigated whether a nonaversive stimulus that had been associated with electric shock would also impair immune function. Presentation of that conditioned stimulus (CS) by itself produced a pronounced suppression of lymphocyte proliferation in response to the nonspecific mitogens, Concanavalin-A (ConA) and Phytohemagglutinin (PHA). In further evidence of a conditioning effect, the suppression was attenuated by extinction and preexposure manipulations that degraded the associative value of the CS. These results indicate that a psychological or learned stressor can suppress immune reactivity independently of the direct effect of physically aversive stimulation or of ancillary changes in dietary and health-related habits.
最近的研究表明，身体应激源，如电击，会抑制大鼠的免疫功能。本研究调查了与电击相关的非厌恶刺激是否也会损害免疫功能。单独呈现该条件刺激（CS）会显著抑制淋巴细胞对非特异性有丝分裂原刀豆蛋白A（ConA）和植物血凝素（PHA）的增殖反应。作为条件作用效应的进一步证据，通过消退和预暴露操作降低CS的关联价值，这种抑制作用会减弱。这些结果表明，心理性或习得性应激源可以独立于身体厌恶刺激的直接影响或饮食及健康相关习惯的辅助性变化来抑制免疫反应性。
