Parbat Dibyangana, Bhunia Bibhas K, Mandal Biman B, Manna Uttam
Bio-Inspired Polymeric Materials Lab, Department of Chemistry, Indian Institute of Technology-Guwahati, Kamrup, Assam, 781039, India.
Biomaterial and Tissue Engineering laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology-Guwahati, Kamrup, Assam, 781039, India.
Chem Asian J. 2021 May 3;16(9):1081-1085. doi: 10.1002/asia.202100143. Epub 2021 Mar 31.
Control promotion and prevention of platelet adhesion are important for various biomedical applications. In the past, surface topography and chemical modifications have been commonly utilized for tailoring the promotion and prevention of platelet adhesion. Recently, lotus-leaf-inspired superhydrophobicity has appeared as an efficient avenue to prevent platelet adhesion. However, such extreme water repellent interfaces fail to perform upon prolonged and continuous exposure to aqueous phase. In this communication, the strategic use of a catalyst-free 1,4-conjugate addition reaction between amine and acrylate allowed us to investigate the impact of two distinct underwater oil-wettability on platelet adhesion activity. While underwater superoleophobicity inhibited platelet-adhesion, a highly aggregated fibrous network of adhered platelets was observed on underwater superoleophilic coating. Further, this biocompatible and haemocompatible underwater superoleophobic multilayer coating was deposited on a commercially available catheter tube to examine its potential towards the prevention of platelet attachment.
控制血小板黏附的促进和预防对于各种生物医学应用都很重要。过去，表面形貌和化学修饰通常用于调整血小板黏附的促进和预防。最近，受荷叶启发的超疏水性已成为防止血小板黏附的有效途径。然而，这种极端的拒水界面在长时间持续暴露于水相时无法发挥作用。在本通讯中，胺与丙烯酸酯之间无催化剂的1,4-共轭加成反应的策略性应用使我们能够研究两种不同的水下油润湿性对血小板黏附活性的影响。虽然水下超疏油性抑制了血小板黏附，但在水下超亲油涂层上观察到了高度聚集的血小板纤维网络。此外，这种生物相容性和血液相容性的水下超疏油多层涂层被沉积在市售的导管上，以检验其预防血小板附着的潜力。
