Tabassian A R, Nylen E S, Giron A E, Snider R H, Cassidy M M, Becker K L
Department of Medicine, George Washington University, Washington, D.C.
Life Sci. 1988;42(23):2323-9. doi: 10.1016/0024-3205(88)90185-3.
In hamsters, acute cigarette smoke inhalation increased serum levels of the hormone calcitonin; and, in humans, smoking of two high-nicotine content cigarettes increased serum and urine levels of this hormone. The source of this immunoreactive calcitonin (iCT) does not appear to be the thyroid gland, since previously thyroidectomized patients demonstrated a similar response. In the hamster, the increased serum iCT levels were accompanied by a decreased lung tissue iCT content and hypocalcemia. It is suggested that the source of the cigarette smoke-induced hypercalcitonemia is the lung, possibly from the iCT-containing pulmonary neuroendocrine (PNE) cells. Moreover, this response appears to be dependent on the nicotine content of the cigarettes.
在仓鼠中，急性吸入香烟烟雾会增加血清中降钙素激素的水平；而在人类中，吸食两支高尼古丁含量的香烟会增加血清和尿液中这种激素的水平。这种免疫反应性降钙素（iCT）的来源似乎不是甲状腺，因为之前接受甲状腺切除术的患者也表现出类似的反应。在仓鼠中，血清iCT水平升高的同时，肺组织iCT含量降低且出现低钙血症。有人认为，香烟烟雾诱导的高降钙素血症的来源是肺，可能来自含iCT的肺神经内分泌（PNE）细胞。此外，这种反应似乎取决于香烟中的尼古丁含量。
