Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, 1-1, Keyakidai, Sakado, Saitama 350-0283, Japan; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Department of Preventive Medicine, College of Medicine, Konyang University, Daejeon, 35365, Republic of Korea.
J Infect Public Health. 2021 Apr;14(4):508-513. doi: 10.1016/j.jiph.2021.01.005. Epub 2021 Jan 11.
Mycobacterium tuberculosis, the bacterium that causes tuberculosis, has long been an unpleasant neighbour of humans. Following transmission of the bacterium from patients with active infection, new hosts do not immediately develop symptoms, as M. tuberculosis initially remains quiescent. However, it is eventually triggered, leading to the infection of other individuals. Humans are the exclusive host, and the rapid proliferation of the human population worldwide along with increasing globalisation have contributed to the pathogen's persistence, as have the survival strategies employed by M. tuberculosis, especially its resistance to several antimicrobials. Defeating this enemy will require novel approaches.
结核分枝杆菌是引起结核病的细菌，长期以来一直是人类的不速之客。在从活动性感染患者传播细菌后，新宿主不会立即出现症状，因为结核分枝杆菌最初处于休眠状态。然而，它最终会被触发，导致其他个体感染。人类是唯一的宿主，全球人口的快速增长以及全球化的加剧，加上结核分枝杆菌所采用的生存策略，特别是其对几种抗生素的耐药性，都促成了该病原体的持续存在。要战胜这个敌人，需要采取新的方法。
