Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Department of Medicine, Queen's University, Kingston Health Sciences Center, Kingston, Ontario, Canada.
Curr Probl Cardiol. 2021 Jun;46(6):100820. doi: 10.1016/j.cpcardiol.2021.100820. Epub 2021 Feb 16.
Chagas' disease (ChD) is a parasitic disease endemic to regions of Latin America and with an increasingly global reach. Up to 30% of patients with ChD develop severe dilated cardiomyopathy, ventricular arrhythmias, conduction disorders and/or sudden cardiac death. Autoantibodies against M muscarinic acetylcholine receptors (M mAChR) have been implicated in the pathogenesis of ChD. We sought to understand whether there was an association between anti-M mAChR autoantibody titers in patients with chronic ChD and the presence of distal cardiac conduction disorders or cardiac arrhythmias. We conducted a cross-sectional study in 79 patients from Argentina and Bolivia with chronic ChD without evident structural heart disease. Autoantibody titers were measured using indirect enzyme-linked immunosorbent assay. Elevated anti-M mAChR autoantibody titers were associated with the presence of distal conduction disease but not with cardiac arrhythmias. High anti-M mAChR autoantibody levels could assist with identifying early structural heart disease in patients with chronic ChD.
恰加斯病（Chagas' disease，ChD）是一种寄生虫病，流行于拉丁美洲地区，且其流行范围正在不断扩大。多达 30%的恰加斯病患者会发展为严重的扩张型心肌病、室性心律失常、传导障碍和/或心源性猝死。针对 M 型毒蕈碱乙酰胆碱受体（M muscarinic acetylcholine receptors，M mAChR）的自身抗体与恰加斯病的发病机制有关。我们试图了解慢性恰加斯病患者的 M mAChR 自身抗体滴度与远端心脏传导障碍或心律失常的存在之间是否存在关联。我们在阿根廷和玻利维亚的 79 名无明显结构性心脏病的慢性恰加斯病患者中开展了一项横断面研究。使用间接酶联免疫吸附测定法测量自身抗体滴度。升高的 M mAChR 自身抗体滴度与远端传导疾病的存在相关，但与心律失常无关。高 M mAChR 自身抗体水平可能有助于识别慢性恰加斯病患者的早期结构性心脏病。
