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虚弱与心脏手术后在家中存活天数的关联:一项基于人群的队列研究。

Association of frailty with days alive at home after cardiac surgery: a population-based cohort study.

机构信息

Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; Institute for Clinical Evaluative Sciences, Ottawa, ON, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, ON, Canada.

出版信息

Br J Anaesth. 2021 Jun;126(6):1103-1110. doi: 10.1016/j.bja.2021.02.011. Epub 2021 Mar 18.

Abstract

BACKGROUND

Frailty is a geriatric syndrome that leaves people vulnerable to adverse outcomes. In cardiac surgery, minimal data describe associations between frailty and patient-centred outcomes. Our objective was to estimate the association between frailty and days alive at home after cardiac surgery.

METHODS

We conducted a population-based cohort study using linked health administrative data in the Canadian province of Ontario. All individuals >65 yr at the time of cardiac surgery were assigned a frailty score using a validated frailty index. Days alive and at home in the 30 and 365 days after surgery were calculated. The unadjusted and adjusted associations between frailty and days alive at home were calculated.

RESULTS

We identified 61 389 patients from 2009 to 2015. Frailty was associated with reduced days at home within 30 days (adjusted ratio of means for every 10% increase in frailty=0.79; 95% confidence interval [CI], 0.78-0.81; P<0.0001) and 365 days (adjusted ratio of means for every 10% increase in frailty=0.92; 95% CI, 0.91-0.93; P<0.0001) of surgery. Results were consistent in sensitivity analyses (5.0 fewer days alive at home [95% CI, 4.8-5.2] within 30 days and 9.0 fewer days alive at home [95% CI, 8.7-9.2] within 365 days after surgery).

CONCLUSION

Frailty is associated with a reduction in days alive at home after major cardiac surgery. This information should be considered in prognostic discussions before surgery and in care planning for vulnerable older patient groups. Days alive at home may be a useful outcome for routine measurement in quality, reporting, and studies using routinely collected data.

摘要

背景

衰弱是一种老年综合征,使人们容易受到不良后果的影响。在心脏手术中,很少有数据描述衰弱与以患者为中心的结果之间的关系。我们的目的是评估衰弱与心脏手术后在家中存活天数之间的关系。

方法

我们使用加拿大安大略省的链接健康管理数据进行了一项基于人群的队列研究。所有在心脏手术时年龄大于 65 岁的个体都使用经过验证的衰弱指数分配了衰弱评分。计算手术后 30 天和 365 天的存活天数和在家中的天数。计算衰弱与在家中存活天数之间的未调整和调整关联。

结果

我们从 2009 年至 2015 年确定了 61389 名患者。衰弱与术后 30 天内(每增加 10%的衰弱,调整后平均比数比=0.79;95%置信区间[CI],0.78-0.81;P<0.0001)和 365 天内(每增加 10%的衰弱,调整后平均比数比=0.92;95%CI,0.91-0.93;P<0.0001)在家中的天数减少有关。敏感性分析结果一致(术后 30 天内,在家中存活的天数减少 5.0 天[95%CI,4.8-5.2];术后 365 天内,在家中存活的天数减少 9.0 天[95%CI,8.7-9.2])。

结论

衰弱与重大心脏手术后在家中存活天数减少有关。这些信息应在手术前的预后讨论中以及脆弱老年患者群体的护理计划中加以考虑。在家中存活的天数可能是常规测量质量、报告和使用常规收集数据进行研究的有用结果。

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