Department of Health Planning Center, Nihon University Hospital, Tokyo Japan; Department of Cardiology, Nihon University Hospital, Tokyo Japan; Department of Medicine, Division of Cardiology, Nihon University School of Medicines, Tokyo, Japan.
Department of Cardiology, Nihon University Hospital, Tokyo Japan; Department of Medicine, Division of Cardiology, Nihon University School of Medicines, Tokyo, Japan.
Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1434-1444. doi: 10.1016/j.numecd.2020.12.031. Epub 2021 Jan 13.
Higher fish consumption may lead to the suppression of atherogenesis. The present study was aimed at investigating the gender differences in association with the frequency of fish intake, lifestyle behaviors and serum non-high-density lipoprotein cholesterol (non-HDL-C) levels.
This cross-sectional study was conducted in a cohort of 4320 (2479 males, 1570 females) healthy Japanese subjects over 50 years of age registered at the Health Planning Center of Nihon University Hospital between April 2018 and March 2019. The average weekly frequency of fish intake was 2.58 ± 1.39 days in males and 2.42 ± 1.36 days in females. In males, the serum non-HDL-C level decreased significantly as the weekly frequency of fish intake (0-1 days, 2-3 days, 4-5 days, or 6-7 days) increased (p < 0.0001). Multiple stepwise regression analysis identified the weekly frequency of fish intake (β = -0.056, p = 0.004) and habitual aerobic exercise (β = -0.063, p = 0.001) as independent determinants of the serum non-HDL-C level. On the other hand, no such associations were observed in females. However, the proportion of subjects engaging in habitual aerobic exercise increased as the frequency of fish intake increased even among females.
A higher frequency of fish intake may be associated with healthier lifestyle behaviors and lower non-HDL-C levels in males, but not in females. There appear to be gender differences in the relationships between the intake of fish and lifestyle behaviors on lipid metabolism.
umin (http://www.umin.ac.jp/) Study ID: UMIN000035899.
较高的鱼类摄入量可能会抑制动脉粥样硬化的发生。本研究旨在调查与鱼类摄入量频率、生活方式行为以及血清非高密度脂蛋白胆固醇（non-HDL-C）水平相关的性别差异。
本横断面研究纳入了 2018 年 4 月至 2019 年 3 月期间在日本国际基督教大学医院健康规划中心登记的 4320 名（男性 2479 名，女性 1570 名）50 岁以上的健康日本受试者。男性每周鱼类摄入量的平均频率为 2.58 ± 1.39 天，女性为 2.42 ± 1.36 天。在男性中，随着每周鱼类摄入量（0-1 天、2-3 天、4-5 天或 6-7 天）的增加，血清 non-HDL-C 水平显著降低（p<0.0001）。多元逐步回归分析确定每周鱼类摄入量（β=-0.056，p=0.004）和习惯性有氧运动（β=-0.063，p=0.001）是血清 non-HDL-C 水平的独立决定因素。另一方面，在女性中未观察到这种关联。然而，即使在女性中，随着鱼类摄入量的增加，进行习惯性有氧运动的比例也会增加。
男性中较高的鱼类摄入量频率可能与更健康的生活方式行为和更低的 non-HDL-C 水平相关，而在女性中则不然。鱼类摄入量与生活方式行为对脂质代谢的关系存在性别差异。
umin（http://www.umin.ac.jp/）研究 ID：UMIN000035899。
