Department of Health Planning Center, Nihon University Hospital, Tokyo, Japan.
Department of Cardiology, Nihon University Hospital, 1-6 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.
Heart Vessels. 2021 Jul;36(7):924-933. doi: 10.1007/s00380-020-01769-9. Epub 2021 Jan 7.
Higher fish consumption has been reported to be associated with a lower incidence of coronary artery disease. We hypothesized that a higher frequency of fish intake may be associated with lower peripheral white blood cell (WBC) counts, a marker of chronic inflammation, which is known to be involved in the development of atherosclerotic cardiovascular disease (ASCVD), and a healthy lifestyle. This cross-sectional study was conducted between April 2018 and August 2018 at the Health Planning Center of Nihon University Hospital in a cohort of 4105 apparently healthy subjects. The average frequency of fish intake was 2.3 ± 1.3 days per week. The WBC count decreased significantly as the frequency of fish intake (0-2 days, 3-4 days, or 5-7 days per week) increased (s < 0.0001). Multivariate linear regression analysis identified higher weekly frequency of fish intake as a significant independent determinant of a lower WBC count (β = - 0.051, p = 0.001). Furthermore, as the weekly frequency of fish intake increased, the proportion of habitual cigarette smokers decreased (p = 0.021), that of subjects engaging in habitual aerobic exercises increased (p < 0.0001), and the weekly alcohol intake frequency increased (p < 0.0001). Moreover, the above-mentioned lifestyle behaviors were also independent determinants of the WBC count. These results suggest that a high frequency of fish intake might be associated with healthier lifestyle behaviors as well as lower WBC counts, and thus may both exert beneficial anti-inflammatory effects and represent a component of healthier lifestyle behaviors associated with a lower risk of ASCVD in Japanese. This association may be partially related to the preventive effects of a higher fish intake on ASCVD events. CLINICAL TRIAL REGISTRATION: UMIN ( http://www.umin.ac.jp/ ) Study ID: UMIN000039197 retrospectively registered 1 February 2020.
较高的鱼类摄入量与冠心病发病率降低有关。我们假设，更频繁地摄入鱼类可能与外周血白细胞（WBC）计数较低有关，而白细胞计数较低是慢性炎症的标志物，已知慢性炎症与动脉粥样硬化性心血管疾病（ASCVD）的发生有关，同时也与健康的生活方式有关。这项横断面研究于 2018 年 4 月至 2018 年 8 月在日本大学医院健康规划中心进行，共有 4105 名看似健康的受试者参加。鱼类摄入量的平均频率为每周 2.3±1.3 天。随着鱼类摄入量（0-2 天、3-4 天或 5-7 天/周）的增加，白细胞计数显著下降（s<0.0001）。多元线性回归分析确定每周更高频率的鱼类摄入是白细胞计数较低的显著独立决定因素（β=−0.051，p=0.001）。此外，随着每周鱼类摄入量的增加，习惯性吸烟者的比例下降（p=0.021），习惯性进行有氧运动的比例增加（p<0.0001），每周饮酒频率增加（p<0.0001）。此外，上述生活方式行为也是白细胞计数的独立决定因素。这些结果表明，高频率的鱼类摄入可能与更健康的生活方式行为以及较低的白细胞计数有关，因此可能同时发挥有益的抗炎作用，并代表与日本 ASCVD 风险降低相关的更健康生活方式行为的组成部分。这种关联可能部分与更高的鱼类摄入对 ASCVD 事件的预防作用有关。临床试验注册：UMIN（http://www.umin.ac.jp/）研究 ID：UMIN000039197 于 2020 年 2 月 1 日回顾性注册。
