Bakoyiannis Ioannis, Kitraki Efthymia, Stamatakis Antonios
Biology-Biochemistry Lab, Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Basic Sciences Lab, Faculty of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Best Pract Res Clin Endocrinol Metab. 2021 Sep;35(5):101517. doi: 10.1016/j.beem.2021.101517. Epub 2021 Mar 10.
Early life exposure to endocrine-disrupting chemicals (EDCs) is considered a potential risk factor for aberrant brain development and the emergence of behavioral deficits. The purpose of this review is to summarize the toxic effects of bisphenol-A (BPA) and phthalate exposure during pre-, -post- or perinatal life on different types of behaviour in male and female rodents. Despite results not being always consistent, most probably due to methodological issues, it is highly probable that early life exposure to BPA or/and phthalates, affects various aspects of behaviour in the offspring. Adverse effects include: Increased levels of anxiety, altered exploratory behaviour, reduced social interaction or increased aggression and deficits in spatial or recognition learning and memory. These effects have been observed with a wide range of doses, in some cases even below the currently employed Tolerable Daily Intake dose for either BPA or phthalates.
早年暴露于内分泌干扰化学物（EDC）被认为是大脑发育异常和行为缺陷出现的潜在风险因素。本综述的目的是总结双酚A（BPA）和邻苯二甲酸盐在产前、产后或围产期暴露对雄性和雌性啮齿动物不同类型行为的毒性作用。尽管结果并非总是一致，很可能是由于方法学问题，但早年暴露于BPA或/和邻苯二甲酸盐极有可能影响后代行为的各个方面。不良影响包括：焦虑水平增加、探索行为改变、社交互动减少或攻击性增加以及空间或识别学习与记忆缺陷。在广泛的剂量范围内都观察到了这些影响，在某些情况下，甚至低于目前针对BPA或邻苯二甲酸盐所采用的每日可耐受摄入量。
