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糖尿病诊断前后避孕措施的使用:一项观察性匹配队列研究。

Use of contraception before and after a diabetes diagnosis: An observational matched cohort study.

机构信息

Department of Population Medicine, Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401 East, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Division of Women's Health, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Prim Care Diabetes. 2021 Aug;15(4):719-725. doi: 10.1016/j.pcd.2021.02.012. Epub 2021 Mar 18.

Abstract

AIMS

To determine how a diabetes diagnosis affects contraception use.

METHODS

This retrospective cohort study used private insurance data from non-pregnant women aged 15-49 years, 2000-2014. We identified women with a new diabetes diagnosis and a control group without diabetes, matched on important potential confounders. We compared rates of prescription or procedural contraception use in the two groups before and after an index date (diabetes diagnosis and outpatient visit, respectively), yielding difference-in-differences estimates of the effect of a diabetes diagnosis on contraception use.

RESULTS

We identified 75,355 women with a new diabetes diagnosis and 7.5 million women without a diabetes diagnosis. Overall rates of contraception use did not increase in the year after diagnosis (absolute difference-in-difference: 0.4% [99.9% CI, -2.1% to 2.9%]; p < 0.001). In method-specific analyses, there was a decline in estrogen-containing and injectable contraceptives in the year after diagnosis (absolute difference-in-difference: -2.2% [-4.0% to -0.4%] and -0.8% [-1.5% to -0.1%], respectively; p < 0.001); no corresponding increase was noted for intrauterine contraception or subdermal implants.

CONCLUSIONS

Women with diabetes are less likely to use contraception after their diabetes diagnosis. Efforts are needed to ensure that women with diabetes receive the counseling and clinical services needed to carefully plan their pregnancies.

摘要

目的

确定糖尿病诊断如何影响避孕措施的使用。

方法

本回顾性队列研究使用了 2000 年至 2014 年期间私人保险数据,纳入年龄在 15-49 岁之间、无妊娠的女性。我们确定了患有新发糖尿病诊断的女性和无糖尿病的对照组女性,并根据重要的潜在混杂因素进行了匹配。我们比较了两组女性在指数日期(糖尿病诊断和门诊就诊)前后的处方或程序避孕措施使用率,得出糖尿病诊断对避孕措施使用影响的差值差异估计。

结果

我们确定了 75355 名新发糖尿病诊断的女性和 750 万名无糖尿病诊断的女性。在诊断后一年内,避孕措施的总体使用率并未增加(绝对差值差异:0.4%[99.9%CI:-2.1%至 2.9%];p<0.001)。在方法特异性分析中,诊断后一年内雌激素避孕药和注射避孕药的使用量下降(绝对差值差异:-2.2%[-4.0%至-0.4%]和-0.8%[-1.5%至-0.1%];p<0.001);宫内节育器或皮下埋植剂的使用量没有相应增加。

结论

糖尿病女性在诊断后更可能不使用避孕措施。需要努力确保糖尿病女性接受所需的咨询和临床服务,以仔细计划怀孕。

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