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长链非编码RNA OGFRP1通过激活人胃癌中的AKT/mTOR信号通路促进肿瘤进展。

lncRNA OGFRP1 promotes tumor progression by activating the AKT/mTOR pathway in human gastric cancer.

作者信息

Zhang Jingzhou, Xu Xiujuan, Yin Junfeng, Tang Jiaqi, Hu Nan, Hong Yidong, Song Ziyan, Bian Baoxiang, Wu Fenglei

机构信息

Department of Oncology, Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China.

Department of Radiation Oncology, Lianyungang Second People's Hospital, Lianyungang, China.

出版信息

Aging (Albany NY). 2021 Mar 19;13(7):9766-9779. doi: 10.18632/aging.202731.

DOI:10.18632/aging.202731
PMID:33744848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8064230/
Abstract

As biomolecules of great clinical value, lncRNAs play a crucial role as regulators in the processes of tumor origin, metastasis, and recurrence. Thus, lncRNAs are urgently needed for research in gastric cancer. We elucidated the specific function of OGFRP1, both and . OGFRP1 was expressed at abnormally high levels in gastric cancer samples (n = 408) compared to normal samples (n = 211). Similar results were obtained in 30 clinical case samples. Interference of OGFRP1 markedly blocked cell proliferation and migration, and it induced cell cycle arrest and the apoptosis of gastric cancer cells . Phosphorylation of AKT was inhibited in cells transfected with OGFRP1 siRNA, as compared to their control cells. The results further confirmed the antitumor effects of OGFRP1 knockdown on gastric cancer. Decreases in tumor volume (104.23±62.27 mm) and weight (0.1006±0.0488 g) in nude mice were observed during the OGFRP1 interference, as compared with the control group (418.96±211.96 mm and 0.2741±0.0769 g). OGFRP1 promotes tumor progression through activating the AKT/mTOR pathway. Our findings provide a new potential target for the clinical treatment of human gastric cancer.

摘要

作为具有重大临床价值的生物分子，长链非编码RNA（lncRNAs）在肿瘤发生、转移和复发过程中作为调节因子发挥着关键作用。因此，胃癌研究迫切需要对lncRNAs进行研究。我们阐明了OGFRP1的具体功能，包括……和……。与正常样本（n = 211）相比，OGFRP1在胃癌样本（n = 408）中表达异常高。在30例临床病例样本中也获得了类似结果。干扰OGFRP1显著阻断细胞增殖和迁移，并诱导胃癌细胞的细胞周期停滞和凋亡。与对照细胞相比，转染OGFRP1 siRNA的细胞中AKT的磷酸化受到抑制。……结果进一步证实了敲低OGFRP1对胃癌的抗肿瘤作用。与对照组（418.96±211.96 mm和0.2741±0.0769 g）相比，在OGFRP1干扰期间观察到裸鼠肿瘤体积（104.23±62.27 mm）和重量（0.1006±0.0488 g）减小。OGFRP1通过激活AKT/mTOR途径促进肿瘤进展。我们的发现为人类胃癌的临床治疗提供了一个新的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/307ee960b548/aging-13-202731-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/790c21346c7b/aging-13-202731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/394955dcb2bb/aging-13-202731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/c4b583cd534b/aging-13-202731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/3deb706b3899/aging-13-202731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/44cbec807659/aging-13-202731-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/7cf74a8bbf62/aging-13-202731-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/307ee960b548/aging-13-202731-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/790c21346c7b/aging-13-202731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/394955dcb2bb/aging-13-202731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/c4b583cd534b/aging-13-202731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/3deb706b3899/aging-13-202731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/44cbec807659/aging-13-202731-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/7cf74a8bbf62/aging-13-202731-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a82f/8064230/307ee960b548/aging-13-202731-g007.jpg

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