Liu Ying, Ding Wei, Yu Wanpeng, Zhang Yuan, Ao Xiang, Wang Jianxun
Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
School of Basic Medical Sciences, Qingdao Medical College, Qingdao University, Qingdao 266071, China.
Mol Ther Oncolytics. 2021 Nov 11;23:458-476. doi: 10.1016/j.omto.2021.11.005. eCollection 2021 Dec 17.
Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and carcinogenesis. The aberrant expression of lncRNAs has been found in various cancer types. A growing amount of evidence demonstrates that lncRNAs are involved in many aspects of GC pathogenesis, including its occurrence, metastasis, and recurrence, indicating their potential role as novel biomarkers in the diagnosis, prognosis, and therapeutic targets of GC. This review systematically summarizes the biogenesis, biological properties, and functions of lncRNAs and highlights their critical role and clinical significance in GC. This information may contribute to the development of better diagnostics and treatments for GC.
胃癌（GC）是全球最常见的恶性肿瘤类型之一，也是癌症相关死亡的第三大主要原因。由于对其发病机制缺乏了解以及新型治疗策略发展缓慢，其发病率和死亡率非常高。长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的非编码RNA。它们通过调节参与增殖、分化、凋亡、细胞周期、侵袭、转移、DNA损伤和致癌作用的基因表达，在广泛的生理和病理过程中发挥关键作用。lncRNAs的异常表达已在各种癌症类型中被发现。越来越多的证据表明，lncRNAs参与了胃癌发病机制的许多方面，包括其发生、转移和复发，表明它们在胃癌的诊断、预后和治疗靶点方面作为新型生物标志物的潜在作用。本综述系统地总结了lncRNAs的生物发生、生物学特性和功能，并强调了它们在胃癌中的关键作用和临床意义。这些信息可能有助于开发更好的胃癌诊断和治疗方法。
