Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
Neuropsychobiology. 2021;80(6):502-515. doi: 10.1159/000514075. Epub 2021 Mar 19.
Vitamin and homocysteine (Hcy) alternations have been associated with psychiatric disorders. The aim of this meta-analysis was to assess the association of serum vitamin and Hcy levels with obsessive-compulsive disorder (OCD). Following PRISMA protocol, we used the databases including Scopus, PubMed, Google Scholar, and Web of Science with no time restriction. Data were pooled using a random-effects model and/or fixed-effects model to estimate the standard mean difference (SMD) for evaluation of the strength of association analyses. Our data showed a significant reduction in vitamin B12 (SMD = -0.58, 95% CI = -1.08 to -0.08, p = 0.02, I2 = 65%; pheterogeneity = 0.06), vitamin E (SMD = -0.89, 95% CI = -1.23 to -0.56, p < 0.00001, I2 = 23%; pheterogeneity = 0.26), and vitamin C (SMD = -1.40, 95% CI = -2.44 to -0.36, p = 0.008, I2 = 92%; pheterogeneity < 0.0001) in OCD patients. In addition, the findings showed significantly higher levels of Hcy (SMD = 1.11, 95% CI = [0.48, 1.75], p = 0.0006, I2 = 73%; ph = 0.02) in patients compared to controls. Also, our data showed that vitamin B9 and D levels are not associated with OCD (vitamin B9: SMD = -0.23, 95% CI = -1.01 to 0.55, p = 0.56, I2 = 88%; pheterogeneity < 0.0001; vitamin D: SMD = -0.63, 95% CI = -1.41 to 0.15, p = 0.11, I2 = 88%; pheterogeneity = 0.0002). Our findings support significant impacts of Hcy and vitamin B12, E, and C levels in OCD pathogenesis. This will be important for prevention and treatment of OCD. However, further studies are recommended to elucidate more accurate conclusions.
维生素和同型半胱氨酸（Hcy）的改变与精神疾病有关。本荟萃分析的目的是评估血清维生素和 Hcy 水平与强迫症（OCD）之间的关联。根据 PRISMA 方案，我们使用了包括 Scopus、PubMed、Google Scholar 和 Web of Science 在内的数据库，没有时间限制。使用随机效应模型和/或固定效应模型汇总数据，以评估关联分析的标准均数差（SMD）。我们的数据显示，维生素 B12（SMD = -0.58，95%CI = -1.08 至 -0.08，p = 0.02，I2 = 65%；p 异质性 = 0.06）、维生素 E（SMD = -0.89，95%CI = -1.23 至 -0.56，p < 0.00001，I2 = 23%；p 异质性 = 0.26）和维生素 C（SMD = -1.40，95%CI = -2.44 至 -0.36，p = 0.008，I2 = 92%；p 异质性 < 0.0001）在 OCD 患者中显著降低。此外，研究结果表明，与对照组相比，OCD 患者的 Hcy 水平显著升高（SMD = 1.11，95%CI = [0.48，1.75]，p = 0.0006，I2 = 73%；ph = 0.02）。此外，我们的数据表明，维生素 B9 和 D 水平与 OCD 无关（维生素 B9：SMD = -0.23，95%CI = -1.01 至 0.55，p = 0.56，I2 = 88%；p 异质性 < 0.0001；维生素 D：SMD = -0.63，95%CI = -1.41 至 0.15，p = 0.11，I2 = 88%；p 异质性 = 0.0002）。我们的研究结果支持 Hcy 和维生素 B12、E 和 C 水平在 OCD 发病机制中的重要作用。这对于 OCD 的预防和治疗非常重要。然而，建议进行进一步的研究以得出更准确的结论。
