Mohammadi Amir Hossein, Balandeh Ebrahim, Milajerdi Alireza
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences (KAUMS), Kashan, Iran.
Ann Gen Psychiatry. 2021 Jun 16;20(1):34. doi: 10.1186/s12991-021-00354-2.
This meta-analysis aimed to investigate serum and plasma malondialdehyde (MDA) levels in patients with obsessive-compulsive disorder (OCD) in comparison to healthy controls.
Following the PRISMA protocol, we searched for the relevant studies through the databases of Scopus, PubMed, Google Scholar, and web of science until September 2019 with no time restriction. Overall, nine studies were included in the current meta-analysis. Data were pooled using a random-effects model; in addition, standard mean difference (SMD) and/or weight mean difference (WMD) was calculated. Cochran's Q test and I-square (I) statistics were used to evaluate between-study heterogeneity. The Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the included studies. Statistical analyses were done using the STATA version 14.
Our systematic review included nine case-control studies (including 367 cases and 337 controls). Pooling findings from these studies showed a significantly higher MDA level in OCD patient compared to control groups (SMD = 1.62; 95% CI [0.53, 2.72]; I = 96.9%; Pheterogeneity (Ph) < 0.001). This finding remained unchanged among studies which reported MDA in the same unit (WMD = 1.93; 95% CI [0.27, 3.59]; I = 99.2%; Ph < 0.001). Subgroup analysis by the study location and sample size revealed findings that were also significant.
We found that MDA levels are higher in OCD patients than healthy controls. This finding highlights the importance of inflammatory responses in OCD patients that should be considered for future investigations. Further studies are recommended to expand current knowledge on this issue.
本荟萃分析旨在研究强迫症（OCD）患者与健康对照者相比血清和血浆丙二醛（MDA）水平。
按照PRISMA方案，我们通过Scopus、PubMed、谷歌学术和科学网数据库检索相关研究，截至2019年9月，无时间限制。总体而言，本荟萃分析纳入了9项研究。数据采用随机效应模型合并；此外，计算了标准均数差（SMD）和/或加权均数差（WMD）。采用Cochran's Q检验和I²（I）统计量评估研究间异质性。采用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。使用STATA 14版进行统计分析。
我们的系统评价纳入了9项病例对照研究（包括367例病例和337例对照）。汇总这些研究的结果显示，与对照组相比，强迫症患者的MDA水平显著更高（SMD = 1.62；95% CI [0.53, 2.72]；I = 96.9%；异质性P值（Ph）< 0.001）。在以相同单位报告MDA的研究中，这一发现保持不变（WMD = 1.93；95% CI [0.27, 3.59]；I = 99.2%；Ph < 0.001）。按研究地点和样本量进行的亚组分析也得出了显著结果。
我们发现强迫症患者的MDA水平高于健康对照者。这一发现凸显了炎症反应在强迫症患者中的重要性，未来研究应予以考虑。建议进一步开展研究以扩展当前对此问题的认识。
