Medical School, Hefei Technology College, Hefei, China.
Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Metab Brain Dis. 2021 Aug;36(6):1101-1108. doi: 10.1007/s11011-021-00709-4. Epub 2021 Mar 20.
Ischemic stroke is one of the most common and undertreated cerebral diseases with high mortality and disability rate. Various intrinsic and extrinsic factors regulate the onset, severity, and progression of ischemic stroke. As an integral part of the neuronal glia system, astrocytes provide many housekeeping functions in nervous system, and perform multiple functions both beneficial and detrimental for neuronal survival after ischemic stroke. In addition, the small GTPase Rho and its downstream Rho kinase (ROCK) are associated with various neuronal functions such as dendrite development, migration and axonal extension, and numerous central nervous system (CNS) diseases. The aim of this review is to summarize the role of RhoA/ROCK signaling pathway and astrocytes on neurological function after ischemic stroke. We also discuss the interaction of RhoA/ROCK signaling pathway and astrocytes on the tissue repair after brain injury.
缺血性脑卒中是最常见和治疗不足的脑部疾病之一，具有高死亡率和残疾率。各种内在和外在因素调节缺血性脑卒中的发病、严重程度和进展。作为神经元胶质系统的一个组成部分，星形胶质细胞在神经系统中提供许多维持生命的功能，并在缺血性脑卒中后对神经元的存活发挥多种有益和有害的功能。此外，小 GTP 酶 Rho 及其下游 Rho 激酶（ROCK）与各种神经元功能有关，如树突发育、迁移和轴突延伸，以及许多中枢神经系统（CNS）疾病。本综述的目的是总结 RhoA/ROCK 信号通路和星形胶质细胞在缺血性脑卒中后神经功能中的作用。我们还讨论了 RhoA/ROCK 信号通路和星形胶质细胞在脑损伤后组织修复中的相互作用。
