Institute of Orthopaedic Research and Biomechanics, Helmholtzstraße 14, 89081 Ulm,
Eur Cell Mater. 2021 Mar 21;41:388-400. doi: 10.22203/eCM.v041a25.
For spinal load and muscle force estimation as well as for numerical model and experimental setup validation, data on human intradiscal pressure are essential. Therefore, the aim of the present meta-analysis was to summarise all in vitro measurements of human intradiscal pressure performed under defined boundary conditions, i.e. without external loading (intrinsic pressure), under axial loading (compression, traction, shear) and under single-planar bending loading (flexion, extension, lateral bending, axial rotation). Data were evaluated based on segmental level and normalised to force and moment. Regression analysis was performed to investigate coefficients of determination and statistical significance of relationships between intradiscal pressure and segmental level for the single loading conditions. 35 studies fulfilled the inclusion criteria, from which a total of 451 data points were collected for the meta-analysis. High coefficients of determination were found in axial compression (r2 = 0.875) and flexion (r2 = 0.781), while being low for intrinsic pressure (r2 = 0.266) and lateral bending (r2 = 0.385), all showing significant regression fitting (p < 0.01). Intradiscal pressure decreases from the upper cervical spine to the sacrum in all loading conditions, considering the same amount of loading for all segmental levels, while the intrinsic pressure exhibits a minimum of the regression curve in the mid-thoracic spine. Apart from its potential for numerical and experimental model validation, this dataset may help to understand the load distribution along the human spine.
对于脊柱负荷和肌肉力的估计以及数值模型和实验设置的验证，椎间盘内压力的数据是必不可少的。因此，本荟萃分析的目的是总结所有在定义边界条件下（即无外部加载（固有压力）、轴向加载（压缩、牵引、剪切）和单平面弯曲加载（屈曲、伸展、侧屈、轴向旋转）下进行的人体椎间盘内压力的体外测量。根据节段水平对数据进行评估，并根据力和力矩进行归一化。回归分析用于研究单加载条件下椎间盘内压力与节段水平之间关系的确定系数和统计学意义。 35 项研究符合纳入标准，共收集了 451 个数据点进行荟萃分析。在轴向压缩（r2 = 0.875）和屈曲（r2 = 0.781）中发现了较高的决定系数，而固有压力（r2 = 0.266）和侧屈（r2 = 0.385）较低，所有这些都显示出显著的回归拟合（p < 0.01）。在所有加载条件下，从颈椎上段到骶骨，椎间盘内压力在考虑到所有节段水平的相同加载量的情况下都降低，而固有压力在胸中段的回归曲线上显示出最小值。除了对数值和实验模型验证的潜在用途外，该数据集还有助于理解人体脊柱的负荷分布。
