Translational Research in Gastrointestinal Disorders, Neurogastroenterology and Motility, Department of Gastroenterology, University of Leuven, Leuven, Belgium.
Translational Research in Gastrointestinal Disorders, Neurogastroenterology and Motility, Department of Gastroenterology, University of Leuven, Leuven, Belgium.
Clin Gastroenterol Hepatol. 2022 Mar;20(3):e429-e437. doi: 10.1016/j.cgh.2021.03.023. Epub 2021 Mar 18.
METHODS: During a GE test (breath test with C-octanoic acid labelled 250 kcal solid meal), the severity of 6 symptoms (postprandial fullness, epigastric pain and burning, bloating, nausea and belching) was assessed, every 15 min, before meal-intake and 4h postprandially. The sum of individual symptom scores generated the meal-related symptoms score; the sum of all symptoms generated overall meal-related symptom severity (OSS). Data were compared in patients with normal and delayed GE (cut-off T≥ 109 min). Data are shown as mean±SEM. RESULTS: 504 patients were included, of which 382 patients (67% female, age 43.8±0.8 years, BMI 23.3±0.2 kg/m) had normal and 122 patients (77% female, age 42.7±1.5 years, BMI 23.2±0.6 kg/m) had delayed GE. OSS tended to be higher in patients with delayed GE (81.8±3.4 vs. 99.5±7.1, p=.05). Only nausea was significantly higher in patients with delayed GE (11±0.8 vs. 16±1.6, p=.01). No correlations were observed between GE rate and any of the symptoms (OSS: r=0.06, p=.2; nausea: r=0.06, p=.1). The symptom severity time course showed a significant difference only for nausea, with increased severity ratings 90 min after the meal (p<.01) in delayed GE compared to normal GE patients. CONCLUSION: The severity of symptoms in functional dyspepsia and idiopathic gastroparesis, even when assessed during the GE test meal, is not correlated to gastric emptying rate. (Ethics committee University Hospital of Leuven study number S55426).
方法：在 GE 测试期间（用 C-辛酸标记的 250 千卡固体餐进行呼气测试），在进食前每 15 分钟评估 6 种症状（餐后饱胀、上腹痛和烧灼感、腹胀、恶心和呃逆）的严重程度，并在餐后 4 小时进行评估。个体症状评分的总和产生与膳食相关的症状评分；所有症状的总和产生整体与膳食相关的症状严重程度（OSS）。在 GE 正常和延迟的患者中比较数据（截止 T≥109 分钟）。数据显示为平均值±SEM。
结果：共纳入 504 例患者，其中 382 例（女性占 67%，年龄 43.8±0.8 岁，BMI 23.3±0.2kg/m）GE 正常，122 例（女性占 77%，年龄 42.7±1.5 岁，BMI 23.2±0.6kg/m）GE 延迟。延迟 GE 的患者 OSS 倾向于更高（81.8±3.4 比 99.5±7.1，p=.05）。只有恶心在延迟 GE 的患者中显著更高（11±0.8 比 16±1.6，p=.01）。GE 率与任何症状之间均无相关性（OSS：r=0.06，p=.2；恶心：r=0.06，p=.1）。仅在延迟 GE 患者中观察到症状严重程度时间进程有显著差异，与正常 GE 患者相比，餐后 90 分钟时恶心严重程度评分增加（p<.01）。
结论：即使在 GE 测试餐期间评估，功能性消化不良和特发性胃轻瘫患者的症状严重程度与胃排空率无关。（鲁汶大学医院伦理委员会研究编号 S55426）。
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