Halawi Houssam, Camilleri Michael, Acosta Andres, Vazquez-Roque Maria, Oduyebo Ibironke, Burton Duane, Busciglio Irene, Zinsmeister Alan R
Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota; and.
Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota; and
Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G442-G447. doi: 10.1152/ajpgi.00190.2017. Epub 2017 Aug 3.
The contributions of gastric emptying (GE) and gastric accommodation (GA) to satiation, satiety, and postprandial symptoms remain unclear. We aimed to evaluate the relationships between GA or GE with satiation, satiety, and postprandial symptoms in healthy overweight or obese volunteers (total = 285, 73% women, mean BMI 33.5 kg/m): 26 prospectively studied obese, otherwise healthy participants and 259 healthy subjects with previous similar GI testing. We assessed GE of solids, gastric volumes, calorie intake at buffet meal, and satiation by measuring volume to comfortable fullness (VTF) and maximum tolerated volume (MTV) by using Ensure nutrient drink test (30 ml/min) and symptoms 30 min after MTV. Relationships between GE or GA with satiety, satiation, and symptoms were analyzed using Spearman rank ( ) and Pearson () linear correlation coefficients. We found a higher VTF during satiation test correlated with a higher calorie intake at ad libitum buffet meal ( = 0.535, < 0.001). There was a significant inverse correlation between gastric half-emptying time (GE ) and VTF ( = -0.317, < 0.001) and the calorie intake at buffet meal ( = -0.329, < 0.001), and an inverse correlation between GE Tlag and GE25% emptied with VTF ( = -0.273, < 0.001 and = -0.248, < 0.001, respectively). GE was significantly associated with satiation (MTV, 0.234, < 0.0001), nausea ( 0.145, = 0.023), pain ( 0.149, = 0.012), and higher aggregate symptom score ( 0.132, = 0.026). There was no significant correlation between GA and satiation, satiety, postprandial symptoms, or GE. We concluded that GE of solids, rather than GA, is associated with postprandial symptoms, satiation, and satiety in healthy participants. A higher volume to comfortable fullness postprandially correlated with a higher calorie intake at ad libitum buffet meal. Gastric emptying of solids is correlated to satiation (volume to fullness and maximum tolerated volume) and satiety (the calorie intake at buffet meal) and symptoms of nausea, pain, and aggregate symptom score after a fully satiating meal. There was no significant correlation between gastric accommodation and either satiation or satiety indices, postprandial symptoms, or gastric emptying.
胃排空（GE）和胃容纳（GA）对饱腹感、饱足感和餐后症状的作用仍不明确。我们旨在评估健康超重或肥胖志愿者（共285例，73%为女性，平均BMI 33.5 kg/m²）中GA或GE与饱腹感、饱足感和餐后症状之间的关系：26例前瞻性研究的肥胖但其他方面健康的参与者以及259例曾进行过类似胃肠检查的健康受试者。我们通过使用安素营养饮料测试（30 ml/分钟）测量达到舒适饱腹感的体积（VTF）和最大耐受体积（MTV）来评估固体食物的GE、胃容积、自助餐时的卡路里摄入量以及饱腹感，并在MTV后30分钟评估症状。使用Spearman秩相关系数（）和Pearson相关系数（）分析GE或GA与饱足感、饱腹感和症状之间的关系。我们发现饱腹感测试期间较高的VTF与随意自助餐时较高的卡路里摄入量相关（ = 0.535，< 0.001）。胃半排空时间（GE ）与VTF（ = -0.317，< 0.001）以及自助餐时的卡路里摄入量（ = -0.329，< 0.001）之间存在显著负相关，并且GE Tlag和GE25%排空量与VTF之间存在负相关（分别为 = -0.273，< 0.001和 = -0.248，< 0.001）。GE 与饱腹感（MTV，0.234，< 0.0001）、恶心（ 0.145， = 0.023）、疼痛（ 0.149， = 0.012）以及较高的总症状评分（ 0.132， = 0.026）显著相关。GA与饱腹感、饱足感、餐后症状或GE之间无显著相关性。我们得出结论，在健康参与者中，固体食物的GE而非GA与餐后症状、饱腹感和饱足感相关。餐后达到舒适饱腹感的较高体积与随意自助餐时较高的卡路里摄入量相关。固体食物的胃排空与饱腹感（达到饱腹感的体积和最大耐受体积）、饱足感（自助餐时的卡路里摄入量）以及饱餐一顿后的恶心、疼痛和总症状评分相关。胃容纳与饱腹感或饱足感指标、餐后症状或胃排空之间均无显著相关性。
