Ann Ital Chir. 2021;92:13-19. Epub 2020 Oct 26.
We aim to evaluate the prognostic significance of tumor volume in esophageal cancer.
Patients who underwent curative resection due to esophageal cancer between the years 2015 and 2019 were included in the study. The Tumor Depth Parameter (TDP) was defined as mucosa and submucosa =1, muscularis propria =2, adventitia =3, and invasion into adjacent organs=4. The Tumor Volume Index (TVI) was defined as the major axis X the minor axis X TDP. Two groups were formed based on TVI: Group 1 (low TVI) and Group 2 (high TVI). In the groups; patients were compared in terms of demographic and clinical features, intraoperative and postoperative outcomes, characteristics of the tumor and average survival.
The patients were divided into two groups based on the cut-off value of 4,000. Group 1 (low TVI) consisted of 16 patients and Group 2 (high TVI) consisted of 28 patients. Male sex ratio was higher in Group 2 (50% vs 85%, p:0.011) Tumor diameter was observed to be larger in Group 2 (3.06 vs 5.54, p:0.000). Adenocarcinoma histologic type was more common in Group 2 (25% vs 64.3%, p:0.012). Incidence of respiratory complications was higher in Group 2 (0% vs 35.7%, p:0.024),Survival time (months) was shorter in Group 2 (36 vs 11, p:0.005). TVI's being over 4000 (HR)(95%-Confidence Interval ((Cl) 0.057 (0.011-0.311),p:0.001) was an independent risk factor to determine the rate of survival.
TVI can be used as a prognostic factor in patients with esophageal cancer who underwent surgical therapy. TVI is closely associated with tumor histology and postoperative outcomes.
Esophageal cancer, Prognosis, Postoperative complication, Surgical manangment, Survey, Tumor volume.
评估食管癌肿瘤体积的预后意义。
纳入 2015 年至 2019 年间因食管癌接受根治性切除术的患者。肿瘤深度参数（TDP）定义为黏膜和黏膜下层=1、固有肌层=2、外膜=3、侵犯相邻器官=4。肿瘤体积指数（TVI）定义为长轴×短轴×TDP。根据 TVI 将患者分为两组：低 TVI 组（TVI＜4000）和高 TVI 组（TVI≥4000）。比较两组间的人口统计学和临床特征、术中及术后结果、肿瘤特征和平均生存时间。
根据 4000 的截断值将患者分为两组。低 TVI 组（16 例）和高 TVI 组（28 例）。高 TVI 组中男性比例更高（50% vs 85%，p=0.011），肿瘤直径更大（3.06 vs 5.54，p=0.000），腺癌组织学类型更常见（25% vs 64.3%，p=0.012）。高 TVI 组呼吸并发症发生率更高（0% vs 35.7%，p=0.024），生存时间（月）更短（36 vs 11，p=0.005）。TVI ＞4000（HR）（95%CI（0.057（0.011-0.311），p=0.001）是影响生存的独立危险因素。
TVI 可作为接受手术治疗的食管癌患者的预后因素。TVI 与肿瘤组织学和术后结果密切相关。
食管癌；预后；术后并发症；外科治疗；调查；肿瘤体积。
