Abdulkareem A O, Babamale O A, Aishat L A, Ajayi O C, Gloria S K, Olatunji L A, Ugbomoiko U S
Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.
HOPE Cardiometabolic Research Research Team, University of Ilorin, Ilorin, Nigeria.
J Parasit Dis. 2021 Mar;45(1):121-127. doi: 10.1007/s12639-020-01272-y. Epub 2020 Oct 11.
Malaria is a global health problem with severe morbidity and mortality in Sub-Saharan Africa. Resistance of spp to the current anti-malaria drugs necessitates further search for novel effective drugs. This study, therefore, investigated the effect of sodium acetate on glucose-6-phosphate dehydrogenase in -infected mice. Thirty male Albino mice were randomly distributed into 6 groups, A-F. Animals in Groups B-F were inoculated with , intraperitoneally. Subsequently, Group C mice were treated with 20 mg/kg chloroquine, while groups D, E and F received 25, 50 and 100 mg/kg sodium acetate, respectively. All treatments were administered orally for 4 days. At the end of the experiment, animals were sacrificed by cervical dislocation and blood was collected via cardiac puncture for the analyses of serum glucose-6-phosphate dehydrogenase (G6PD), uric acid and lipid profile. Our results showed that Sodium acetate (50 and 100 mg/kg) significantly reduced ( < 0.05) parasitaemia (67.11% and 77.62%, respectively) than chloroquine (61.73%). Besides, body weight and serum G6PD activity in infection were improved. Similarly, sodium acetate reduced elevated serum uric acid. Effects of sodium acetate and chloroquine on biochemical parameters were comparable ( > 0.05) but atherogenic lipid ratios were not affected by sodium acetate. These data put together suggested that activity of sodium acetate may be harnessed for development of novel anti-malaria drugs. However, more studies are required to delineate its mechanisms of action.
疟疾是一个全球性的健康问题，在撒哈拉以南非洲地区导致严重的发病和死亡。疟原虫对当前抗疟药物产生耐药性，因此有必要进一步寻找新型有效药物。因此，本研究调查了乙酸钠对感染疟原虫小鼠葡萄糖-6-磷酸脱氢酶的影响。30只雄性白化小鼠随机分为6组，A - F组。B - F组动物腹腔注射疟原虫。随后，C组小鼠用20mg/kg氯喹治疗，而D、E和F组分别接受25、50和100mg/kg乙酸钠治疗。所有治疗均口服给药4天。实验结束时，通过颈椎脱臼处死动物，并通过心脏穿刺采血，用于分析血清葡萄糖-6-磷酸脱氢酶（G6PD）、尿酸和血脂谱。我们的结果表明，乙酸钠（50和100mg/kg）比氯喹（61.73%）显著降低（P<0.05）疟原虫血症（分别为67.11%和77.62%）。此外，疟原虫感染小鼠的体重和血清G6PD活性得到改善。同样，乙酸钠降低了血清尿酸水平。乙酸钠和氯喹对生化参数的影响相当（P>0.05），但乙酸钠对致动脉粥样硬化脂质比率没有影响。综合这些数据表明，乙酸钠的活性可用于开发新型抗疟药物。然而，需要更多的研究来阐明其作用机制。
