皮肤利什曼病患者血清中CC趋化因子配体水平
Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients.
作者信息
Hassanshahi Gholamhossein, Alavi Seyed Ebrahim, Khorramdelazad Hossein, Ahmadi Zahra, Fattahi Bafghi Ali, Abdollahi Seyed Hossein, Ebrahimi Shahmabadi Hasan
机构信息
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, P.O. Box 771751-735, Rafsanjan, Iran.
Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
J Parasit Dis. 2021 Mar;45(1):153-158. doi: 10.1007/s12639-020-01290-w. Epub 2020 Oct 14.
The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.
趋化因子/受体在包括利什曼病在内的多种寄生虫感染中的关键作用已有充分记载。本研究旨在评估皮肤利什曼病（CL）患者血清中CC配体（CCL）2、CCL5和CCL11的水平。选取了64例CL患者和100名健康人，采用酶联免疫吸附测定法检测他们血清中CCL2、CCL5和CCL11的浓度。结果表明，与对照组相比，CL患者血清中CCL5和CCL11的平均水平显著升高，而CCL2的平均水平降低。尽管CL患者体内CCL5和CCL11产生充足，但作为抵抗寄生虫感染的防御机制，他们存在CCL2缺乏的情况。这些发现提示了一种机制，可能部分解释了患者对持续性感染的易感性以及清除寄生虫的无能。
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