• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫反应CC趋化因子CCL2和CCL5与肺结节病相关。

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis.

作者信息

Palchevskiy Vyacheslav, Hashemi Nastran, Weigt Stephen S, Xue Ying Ying, Derhovanessian Ariss, Keane Michael P, Strieter Robert M, Fishbein Michael C, Deng Jane C, Lynch Joseph P, Elashoff Robert, Belperio John A

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Department of Medicine, St Vincent's University Hospital and University College Dublin, Dublin, Ireland.

出版信息

Fibrogenesis Tissue Repair. 2011 Apr 4;4:10. doi: 10.1186/1755-1536-4-10.

DOI:10.1186/1755-1536-4-10
PMID:21463523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3080805/
Abstract

BACKGROUND

Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis. In an effort to clarify previous discrepancies, we performed the largest observational study to date of CC chemokines in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis.

RESULTS

BALF chemokine levels from 72 patients affected by pulmonary sarcoidosis were analyzed by enzyme-linked immunosorbent assay (ELISA) and compared to 8 healthy volunteers. BALF CCL3 and CCL4 levels from pulmonary sarcoidosis patients were not increased compared to controls. However, CCL2 and CCL5 levels were elevated, and subgroup analysis showed higher levels of both chemokines in all stages of pulmonary sarcoidosis. CCL2, CCL5, CC chemokine receptor type 1 (CCR1), CCR2 and CCR3 were expressed from mononuclear cells forming the lung granulomas, while CCR5 was only found on mast cells.

CONCLUSIONS

These data suggest that CCL2 and CCL5 are important mediators in recruiting CCR1, CCR2, and CCR3 expressing mononuclear cells as well as CCR5-expressing mast cells during all stages of pulmonary sarcoidosis.

摘要

背景

肺结节病表现为肺部有强烈的白细胞浸润，并形成非坏死性肉芽肿。CC趋化因子（趋化因子（C-C基序）配体2（CCL2）-CCL5）是单核细胞的趋化剂，通过七个跨膜G偶联受体发挥作用。先前的研究在这些趋化因子与结节病的关联方面得出了相互矛盾的结果。为了澄清先前的差异，我们进行了迄今为止关于肺结节病患者支气管肺泡灌洗液（BALF）中CC趋化因子的最大规模观察性研究。

结果

通过酶联免疫吸附测定（ELISA）分析了72例肺结节病患者的BALF趋化因子水平，并与8名健康志愿者进行了比较。与对照组相比，肺结节病患者的BALF CCL3和CCL4水平没有升高。然而，CCL2和CCL5水平升高，亚组分析显示在肺结节病的所有阶段这两种趋化因子的水平都更高。CCL2、CCL5、CC趋化因子受体1型（CCR1）、CCR2和CCR3在形成肺肉芽肿的单核细胞中表达，而CCR5仅在肥大细胞上发现。

结论

这些数据表明，在肺结节病的所有阶段，CCL2和CCL5是招募表达CCR1、CCR2和CCR3的单核细胞以及表达CCR5的肥大细胞的重要介质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/089d95ccdf49/1755-1536-4-10-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/a246419ffdb7/1755-1536-4-10-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/d34f05ced057/1755-1536-4-10-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/eb95707f581d/1755-1536-4-10-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/7f949f4a7f30/1755-1536-4-10-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/d5dc557e7f0a/1755-1536-4-10-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/089d95ccdf49/1755-1536-4-10-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/a246419ffdb7/1755-1536-4-10-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/d34f05ced057/1755-1536-4-10-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/eb95707f581d/1755-1536-4-10-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/7f949f4a7f30/1755-1536-4-10-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/d5dc557e7f0a/1755-1536-4-10-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7afa/3080805/089d95ccdf49/1755-1536-4-10-6.jpg

相似文献

1
Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis.免疫反应CC趋化因子CCL2和CCL5与肺结节病相关。
Fibrogenesis Tissue Repair. 2011 Apr 4;4:10. doi: 10.1186/1755-1536-4-10.
2
CC and C chemokine expression in pulmonary sarcoidosis.肺结节病中CC和C趋化因子的表达
Eur Respir J. 2002 Nov;20(5):1206-12. doi: 10.1183/09031936.02.00289902.
3
Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases.趋化因子及趋化因子受体在炎性根尖周病中的差异表达
Oral Microbiol Immunol. 2005 Oct;20(5):310-6. doi: 10.1111/j.1399-302X.2005.00232.x.
4
CCL3/CCR1 mediates CD14CD16 circulating monocyte recruitment in knee osteoarthritis progression.CCL3/CCR1 介导 CD14CD16 循环单核细胞在膝关节骨关节炎进展中的募集。
Osteoarthritis Cartilage. 2020 May;28(5):613-625. doi: 10.1016/j.joca.2020.01.009. Epub 2020 Jan 29.
5
Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice.在实验性牙周炎中，趋化因子 CCL3、CCL4 和 CCL5 及其受体 CCR1+和 CCR5+在 RANKL+细胞迁移中的协同作用的证据。
Bone. 2010 Apr;46(4):1122-30. doi: 10.1016/j.bone.2009.12.030. Epub 2010 Jan 4.
6
Annulus fibrosus cells express and utilize C-C chemokine receptor 5 (CCR5) for migration.纤维环细胞表达并利用C-C趋化因子受体5（CCR5）进行迁移。
Spine J. 2017 May;17(5):720-726. doi: 10.1016/j.spinee.2017.01.010. Epub 2017 Jan 17.
7
Elevated concentrations of liver-expressed chemokine/CC chemokine ligand 16 in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia.嗜酸性粒细胞性肺炎患者支气管肺泡灌洗液中肝脏表达趋化因子/CC趋化因子配体16浓度升高。
Int Arch Allergy Immunol. 2009;150(3):282-90. doi: 10.1159/000222681. Epub 2009 Jun 4.
8
CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.CCL2/CCR2而非CCL5/CCR5介导骨关节炎中单核细胞募集、炎症及软骨破坏。
Ann Rheum Dis. 2017 May;76(5):914-922. doi: 10.1136/annrheumdis-2016-210426. Epub 2016 Dec 13.
9
CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis.特发性肺纤维化中CCR5的表达及CC趋化因子水平
Eur Respir J. 2005 Apr;25(4):701-7. doi: 10.1183/09031936.05.00082604.
10
Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells.趋化因子信号对于循环破骨细胞祖细胞的归巢和分化增强至关重要。
Arthritis Res Ther. 2017 Jun 15;19(1):142. doi: 10.1186/s13075-017-1337-6.

引用本文的文献

1
Oral cell lysates reduce osteoclastogenesis in murine bone marrow cultures.口腔细胞裂解物可减少小鼠骨髓培养物中的破骨细胞生成。
Cytotechnology. 2025 Feb;77(1):39. doi: 10.1007/s10616-024-00688-1. Epub 2025 Jan 8.
2
DNA Polymorphisms and mRNA Levels of Immune Biomarkers as Candidates for Inflammatory Postpartum Disorders Susceptibility in Italian Buffaloes.作为意大利水牛炎症性产后疾病易感性候选指标的免疫生物标志物的DNA多态性和mRNA水平
Vet Sci. 2023 Sep 14;10(9):573. doi: 10.3390/vetsci10090573.
3
Human T-cell Lymphotropic Virus Type-1-associated Bronchioloalveolar Disorder with Non-necrotizing Granulomas: A Case Report and Literature Review.

本文引用的文献

1
CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis.CXCR3 配体在肺结节病发病机制中增强。
Eur Respir J. 2009 Sep;34(3):676-86. doi: 10.1183/09031936.00157508. Epub 2009 Apr 22.
2
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages.结节病患者体内的CXCL9和CXCL11：肺泡巨噬细胞的作用
Clin Exp Immunol. 2007 Aug;149(2):317-26. doi: 10.1111/j.1365-2249.2007.03423.x. Epub 2007 Jun 5.
3
Lung transplantation in sarcoidosis.结节病中的肺移植
1型人类嗜T细胞病毒相关的细支气管肺泡疾病伴非坏死性肉芽肿：一例报告及文献复习
Intern Med. 2024 Apr 15;63(8):1149-1155. doi: 10.2169/internalmedicine.2201-23. Epub 2023 Sep 1.
4
Molecular Mechanism in the Development of Pulmonary Fibrosis in Patients with Sarcoidosis.结节病患者肺纤维化发展中的分子机制。
Int J Mol Sci. 2023 Jun 28;24(13):10767. doi: 10.3390/ijms241310767.
5
Targeting Features of Curaxin CBL0137 on Hematological Malignancies In Vitro and In Vivo.Curaxin CBL0137对血液系统恶性肿瘤的体内外靶向作用特征
Biomedicines. 2023 Jan 16;11(1):230. doi: 10.3390/biomedicines11010230.
6
Pharmacological Inhibition of Chitotriosidase (CHIT1) as a Novel Therapeutic Approach for Sarcoidosis.壳三糖苷酶（CHIT1）的药理学抑制作为结节病的一种新型治疗方法
J Inflamm Res. 2022 Sep 29;15:5621-5634. doi: 10.2147/JIR.S378357. eCollection 2022.
7
Sarcoidosis: Progression to the chronic stage and pathogenic based treatment (narrative review).结节病：进展至慢性期及基于发病机制的治疗（综述）
Front Med (Lausanne). 2022 Sep 6;9:963435. doi: 10.3389/fmed.2022.963435. eCollection 2022.
8
A Polymorphism in C-C Chemokine Receptor 5 (CCR5) Associates with Löfgren's Syndrome and Alters Receptor Expression as well as Functional Response.C-C 趋化因子受体 5（CCR5）的多态性与 Löfgren 综合征相关，并改变受体表达和功能反应。
Cells. 2021 Aug 3;10(8):1967. doi: 10.3390/cells10081967.
9
Extrapulmonary sarcoidosis with a focus on cardiac, nervous system, and ocular involvement.以心脏、神经系统和眼部受累为重点的肺外结节病。
EClinicalMedicine. 2021 Jun 27;37:100966. doi: 10.1016/j.eclinm.2021.100966. eCollection 2021 Jul.
10
Studies in a Murine Granuloma Model of Instilled Carbon Nanotubes: Relevance to Sarcoidosis.在注入碳纳米管的鼠类肉芽肿模型中的研究：与类肉瘤病的相关性。
Int J Mol Sci. 2021 Apr 2;22(7):3705. doi: 10.3390/ijms22073705.
Semin Respir Crit Care Med. 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339.
4
Idiopathic interstitial pneumonias: Primum movens: epithelial, endothelial or whatever.特发性间质性肺炎：原动力：上皮细胞、内皮细胞或其他任何细胞。
Sarcoidosis Vasc Diffuse Lung Dis. 2005 Dec;22 Suppl 1:S15-23.
5
Cytokines, chemokines and other biomolecular markers in sarcoidosis.结节病中的细胞因子、趋化因子及其他生物分子标志物
Sarcoidosis Vasc Diffuse Lung Dis. 2005 Dec;22 Suppl 1:S9-14.
6
Role of the chemokine receptors CXCR3 and CCR4 in human pulmonary fibrosis.趋化因子受体CXCR3和CCR4在人类肺纤维化中的作用。
Am J Respir Crit Care Med. 2006 Feb 1;173(3):310-7. doi: 10.1164/rccm.200502-244OC. Epub 2005 Oct 20.
7
Study of C-C chemokine receptor 2 alleles in sarcoidosis, with emphasis on family-based analysis.结节病中C-C趋化因子受体2等位基因的研究，重点是基于家系的分析。
Am J Respir Crit Care Med. 2005 May 15;171(10):1136-41. doi: 10.1164/rccm.200405-658OC. Epub 2005 Mar 4.
8
The chemokine system in diverse forms of macrophage activation and polarization.不同形式巨噬细胞活化与极化中的趋化因子系统
Trends Immunol. 2004 Dec;25(12):677-86. doi: 10.1016/j.it.2004.09.015.
9
High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia.与寻常型间质性肺炎相比，非特异性间质性肺炎中RANTES的高BAL液浓度。
Respir Med. 2004 Oct;98(10):945-51. doi: 10.1016/j.rmed.2004.03.008.
10
Pulmonary sarcoidosis.肺结节病
Clin Chest Med. 2004 Sep;25(3):521-30, vi. doi: 10.1016/j.ccm.2004.04.006.