Picard Marie-Ève, Cusson Michel, Sen Stephanie E, Shi Rong
Département de biochimie, de microbiologie et de bio-informatique, Institut de Biologie Intégrative et des Systèmes, PROTEO, Université Laval, Quebec City, QC, G1V 0A6, Canada.
Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, 1055 du P.E.P.S., P.O. Box 10380, Station Ste. Foy, Quebec City, QC, G1V 4C7, Canada.
J Pestic Sci. 2021 Feb 20;46(1):7-15. doi: 10.1584/jpestics.D20-078.
Reducing the use of broad-spectrum insecticides is one of the many challenges currently faced by insect pest management practitioners. For this reason, efforts are being made to develop environmentally benign pest-control products through bio-rational approaches that aim at disrupting physiological processes unique to specific groups of pests. Perturbation of hormonal regulation of insect development and reproduction is one such strategy. It has long been hypothesized that some enzymes in the juvenile hormone biosynthetic pathway of moths, butterflies and caterpillars (order Lepidoptera) display unique structural features that could be targeted for the development of Lepidoptera-specific insecticides, a promising avenue given the numerous agricultural and forest pests belonging to this order. Farnesyl diphosphate synthase, FPPS, is one such enzyme, with recent work suggesting that it has structural characteristics that may enable its selective inhibition. This review synthesizes current knowledge on FPPS and summarizes recent advances in its use as a target for insecticide development.
减少广谱杀虫剂的使用是害虫管理从业者目前面临的众多挑战之一。因此，人们正在努力通过生物合理的方法开发对环境无害的害虫控制产品，这些方法旨在扰乱特定害虫群体特有的生理过程。干扰昆虫发育和繁殖的激素调节就是这样一种策略。长期以来，人们一直推测，蛾、蝴蝶和毛虫（鳞翅目）的保幼激素生物合成途径中的一些酶具有独特的结构特征，可作为开发鳞翅目特异性杀虫剂的靶点，鉴于该目有众多农业和森林害虫，这是一条很有前景的途径。法尼基二磷酸合酶（FPPS）就是这样一种酶，最近的研究表明它具有可能使其受到选择性抑制的结构特征。本综述综合了关于FPPS的现有知识，并总结了其作为杀虫剂开发靶点的最新进展。
