Jindra Marek
Biology Center of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice 370 05, Czech Republic.
J Pestic Sci. 2021 Feb 20;46(1):3-6. doi: 10.1584/jpestics.M21-03.
Insect Growth Regulators (IGRs) represent advanced, bio-rational insecticides. This Special Issue reflects progress in IGR development that has been enabled by insight into the molecular principles of biosynthetic or hormone signaling pathways. The unifying principle is aiming at processes and molecular targets that are unique to arthropods and ideally to narrower insect taxa representing pests or disease vectors. While some strategies of obtaining the desired compounds for chemical intervention rely on rational, structure-based design or computational power, others exploit technologies allowing automated, high-throughput screening of large chemical libraries. All avenues leading to selective and environmentally safe pest control are valid as we face the imminent threat of the declining world insect population.
昆虫生长调节剂（IGRs）是先进的、具有生物合理性的杀虫剂。本期特刊反映了IGR开发方面的进展，这一进展得益于对生物合成或激素信号通路分子原理的深入了解。其统一原则是针对节肢动物特有的过程和分子靶点，理想情况下是针对代表害虫或病媒的更狭义昆虫类群。虽然获取用于化学干预的所需化合物的一些策略依赖于合理的、基于结构的设计或计算能力，但其他策略则利用允许对大型化学文库进行自动化高通量筛选的技术。在我们面临世界昆虫种群数量下降这一紧迫威胁之际，所有通向选择性和环境安全害虫控制的途径都是有效的。
