Satoh Eikoh, Kasahara Ryota, Fukatsu Kosuke, Aoki Takao, Harayama Hiroto, Murata Tetsuya
Research Center, Research Division, Nihon Nohyaku Co., Ltd., 345 Oyamada-cho, Kawachi-nagano, Osaka 586-0094, Japan.
J Pestic Sci. 2021 Feb 20;46(1):109-114. doi: 10.1584/jpestics.D20-069.
Benzpyrimoxan (5-(1,3-dioxan-2-yl)-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrimidine, NNI-1501) was discovered as a novel insecticide structurally characterized by a pyrimidine derivative substituted with 1,3-dioxanyl and 4-trifluoromethylbenzyloxy groups. The compound showed remarkable activity against nymphs of rice planthoppers, including strains resistant to existing insecticides. Furthermore, benzpyrimoxan had low adverse effects on pollinators and beneficial arthropods. Because of these features, benzpyrimoxan is expected to be a suitable part of an integrated pest management strategy. In this report, the history of the discovery to reach benzpyrimoxan and details of the structure-activity relationships are described.
苯嘧虫酰胺（5-(1,3-二氧杂环己烷-2-基)-4-{[4-(三氟甲基)苯基]甲氧基}嘧啶，NNI-1501）是作为一种新型杀虫剂被发现的，其结构特征为嘧啶衍生物被1,3-二氧杂环己烷基和4-三氟甲基苄氧基取代。该化合物对稻飞虱若虫表现出显著活性，包括对现有杀虫剂具有抗性的品系。此外，苯嘧虫酰胺对传粉者和有益节肢动物的不良影响较低。由于这些特性，苯嘧虫酰胺有望成为综合害虫管理策略的合适组成部分。在本报告中，描述了发现苯嘧虫酰胺的历程以及构效关系的详细情况。
