Rasi Bonab Farnaz, Baghbanzadeh Amir, Ghaseminia Moslem, Bolandi Nadia, Mokhtarzadeh Ahad, Amini Mohammad, Dadashzadeh Kianoosh, Hajiasgharzadeh Khalil, Baradaran Behzad, Bannazadeh Baghi Hossein
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Laboratory Sciences, Marand Branch, Islamic Azad University, Marand, Iran.
EXCLI J. 2021 Feb 12;20:320-337. doi: 10.17179/excli2021-3365. eCollection 2021.
Recently, human papillomavirus (HPV) has gained considerable attention in cervical cancer research studies. It is one of the most important sexually transmitted diseases that can affect 160 to 289 out of 10000 persons every year. Due to the infectious nature of this virus, HPV can be considered a serious threat. The knowledge of viral structure, especially for viral oncoproteins like E6, E7, and their role in causing cancer is very important. This virus has different paths (PI3K/Akt, Wnt/β-catenin, ERK/MAPK, and JAK/STAT) that are involved in the transmission of signaling paths through active molecules like MEK (pMEK), ERK (pERK), and Akt (pAkt). It's eventually through these paths that cancer is developed. Precise knowledge of these paths and their signals give us the prognosis to adopt appropriate goals for prevention and control of these series of cancer.
最近，人乳头瘤病毒（HPV）在宫颈癌研究中受到了广泛关注。它是最重要的性传播疾病之一，每年每10000人中就有160至289人受其影响。由于这种病毒具有传染性，HPV可被视为一种严重威胁。了解病毒结构，特别是像E6、E7这样的病毒癌蛋白及其在致癌过程中的作用非常重要。这种病毒有不同的信号通路（PI3K/Akt、Wnt/β-连环蛋白、ERK/MAPK和JAK/STAT），这些通路通过MEK（pMEK）、ERK（pERK）和Akt（pAkt）等活性分子参与信号传导。最终正是通过这些通路才引发癌症。准确了解这些通路及其信号，能让我们为预防和控制这一系列癌症制定合适目标并做出预后判断。
