Aziz Aziz Ur Rehman, Zhang Jianing, Zhang Chan, Yu Xiaohui, Wang Daqing
Key Laboratory for Early Diagnosis and Biotherapy of Malignant Tumors in Children and Women, Dalian Women and Children's Medical Group, Dalian, Liaoning 116012, P.R. China.
Mol Clin Oncol. 2024 Jul 18;21(4):67. doi: 10.3892/mco.2024.2765. eCollection 2024 Oct.
Cervical cancer is a significant global health concern, with a substantial portion of cases attributed to human papillomavirus (HPV) infection. Recent advancements in molecular profiling have identified distinct subtypes of cervical cancer based on their genomic alterations. One such subgroup is neurotrophic tropomyosin receptor kinase (NTRK) fusion-positive cervical cancers, characterized by gene fusions involving the NTRK genes. Although both NTRK fusion genes and HPV infections are independently recognized as significant risk factors in cervical cancer, their interplay and mutual effects on cancer progression are not yet fully understood. The present review is the first of its kind to explore the potential interplay between NTRK fusion genes and HPV infections. It surveys in detail how their combined effect can influence the signaling pathways during cervical cancer development and progression. Moreover, the present study discussed the clinical features, histopathological examinations, treatment procedures and follow-up outcomes of NTRK-fusion gene-positive cervical cancer. The present review may help in the understanding of the management and treatment of such rare, lethal and resistant cervical cancers.
宫颈癌是一个重大的全球健康问题，相当一部分病例归因于人类乳头瘤病毒（HPV）感染。分子图谱分析的最新进展已根据基因组改变确定了宫颈癌的不同亚型。其中一个亚组是神经营养性原肌球蛋白受体激酶（NTRK）融合阳性宫颈癌，其特征是涉及NTRK基因的基因融合。尽管NTRK融合基因和HPV感染均被独立认为是宫颈癌的重要危险因素，但它们在癌症进展中的相互作用和相互影响尚未完全了解。本综述是同类研究中首次探讨NTRK融合基因与HPV感染之间潜在相互作用的研究。它详细调查了它们的联合作用如何影响宫颈癌发生和发展过程中的信号通路。此外，本研究讨论了NTRK融合基因阳性宫颈癌的临床特征、组织病理学检查、治疗程序和随访结果。本综述可能有助于理解此类罕见、致命且耐药的宫颈癌的管理和治疗。
