Dange Suhani, Aggarwal Neha, Verma Rivi, Sinha Yashika, Dadhiya Sonakshi, Mittal Gagan, Sachdeva Ruchi
Department of Bioinformatics, Goswami Ganesh Dutta Sanatan Dharma College, Sector-32, Chandigarh, India.
Department of Biotechnology, Panjab University, Chandigarh, India.
Mol Biol Res Commun. 2025;14(2):129-141. doi: 10.22099/mbrc.2024.51173.2038.
Cervical cancer is one of the common types of cancer in women. Treatment regimens include use of chemotherapy but it leads to certain side effects thereby creating a need for safer therapeutic options. Ayurveda has a great potential to provide better treatment strategies. In this study, computational approaches have been employed to investigate the molecular mechanism of anti-cervical cancer Ayurvedic herbs. Initially, Ayurvedic plants possessing anti-cervical cancer activities were obtained from literature. Bioactive compounds present in such plants were evaluated for drug-likeliness, biological functions and associations with cancer-related pathways. This resulted in the most promising drug-like bioactive compounds which were found to target cancer pathways like microRNA and proteoglycans, Human papillomavirus infection. Anti-cervical cancer activity possessing herbs derived from the study include Major bioactive compounds extracted from the enlisted herbs that contribute in promoting anti-cervical cancer effects include allicin, apigenin, and mataresinol. Overall, our study has provided insights into the scientific mechanism behind anti-cervical cancer activities of the indigenous herbs of Ayurveda. In addition, this study has also highlighted key bioactive compounds which have a potential in targeting cancer related pathways and thus can further be utilized to devise better therapeutics to cure cervical cancer.
宫颈癌是女性常见的癌症类型之一。治疗方案包括使用化疗，但化疗会导致某些副作用，因此需要更安全的治疗选择。阿育吠陀医学有很大潜力提供更好的治疗策略。在本研究中，已采用计算方法来研究阿育吠陀抗宫颈癌草药的分子机制。最初，从文献中获取具有抗宫颈癌活性的阿育吠陀植物。评估此类植物中存在的生物活性化合物的类药性质、生物学功能以及与癌症相关途径的关联。这产生了最有前景的类药生物活性化合物，发现它们靶向如微小RNA和蛋白聚糖、人乳头瘤病毒感染等癌症途径。该研究中具有抗宫颈癌活性的草药包括 从所列草药中提取的主要生物活性化合物，有助于促进抗宫颈癌作用的包括大蒜素、芹菜素和mataresinol。总体而言，我们的研究深入了解了阿育吠陀本土草药抗宫颈癌活性背后的科学机制。此外，本研究还突出了关键生物活性化合物，它们有潜力靶向癌症相关途径，因此可进一步用于设计更好的治疗方法来治愈宫颈癌。
