COVID-19 Research Center, The First School of Clinical Medicine, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Southern Medical University, Nanjing, China.
Medical and Technical Support Department, Pingdingshan Medical District, The 989th Hospital Pingingshan, Pingdingshan, China.
Front Immunol. 2021 Mar 4;12:598799. doi: 10.3389/fimmu.2021.598799. eCollection 2021.
A comprehensive understanding of the dynamic changes in interleukin-6 (IL-6) levels is essential for monitoring and treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). By analyzing the correlations between IL-6 levels and health conditions, underlying diseases, several key laboratory detection indices, and the prognosis of 1,473 patients with the coronavirus disease 2019 (COVID-19), the role of IL-6 during SARS-CoV-2 infection was demonstrated. Our results indicated that IL-6 levels were closely related to age, sex, body temperature, oxygen saturation (SpO) of blood, and underlying diseases. As a stable indicator, the changes in IL-6 levels could indicate the inflammatory conditions during a viral infection. Two specific treatments, namely, tocilizumab and convalescent plasma therapy (CPT), decreased the level of IL-6 and relieved inflammation. CPT has an important role in the therapy for patients with critical COVID-19. We also found that patients with IL-6 levels, which were 30-fold higher than the normal level, had a poor prognosis compared to patients with lower levels of IL-6.
全面了解白细胞介素-6 (IL-6) 水平的动态变化对于监测和治疗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的患者至关重要。通过分析 1473 例 2019 冠状病毒病 (COVID-19) 患者的 IL-6 水平与健康状况、基础疾病、几项关键实验室检测指标以及预后之间的相关性，研究了 IL-6 在 SARS-CoV-2 感染中的作用。结果表明，IL-6 水平与年龄、性别、体温、血氧饱和度 (SpO) 和基础疾病密切相关。作为一个稳定的指标，IL-6 水平的变化可以反映病毒感染期间的炎症情况。两种特定的治疗方法，即托珠单抗和恢复期血浆治疗 (CPT)，降低了 IL-6 水平并缓解了炎症。CPT 在治疗重症 COVID-19 患者中具有重要作用。我们还发现，IL-6 水平是正常水平的 30 倍的患者与 IL-6 水平较低的患者相比预后较差。
