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前房内注射莫西沙星所致毒性眼前节综合征：病例报告及文献复习

Toxic Anterior Segment Syndrome with Intracameral Moxifloxacin: Case Report and Review of the Literature.

作者信息

Amireskandari Annahita, Bean Andrew, Mauger Thomas

机构信息

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.

出版信息

Case Rep Ophthalmol Med. 2021 Mar 2;2021:5526097. doi: 10.1155/2021/5526097. eCollection 2021.

DOI:10.1155/2021/5526097
PMID:33747588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7943300/
Abstract

A case of severe anterior segment toxicity secondary to high-volume, undiluted intracameral moxifloxacin for endophthalmitis prophylaxis is reported. We examine the other reported cases of toxicity after intracameral moxifloxacin, as well as iris depigmentation and transillumination syndromes after oral and topical fluoroquinolone exposure. Additionally, we review the literature on safety, efficacy, and appropriate dosing of intracameral antibiotics with a focus on moxifloxacin.

摘要

报告了1例因使用高容量、未稀释的前房内莫西沙星预防眼内炎而继发严重眼前节毒性的病例。我们研究了其他已报道的前房内注射莫西沙星后出现毒性的病例，以及口服和局部使用氟喹诺酮类药物后出现的虹膜色素脱失和透照综合征。此外，我们回顾了关于前房内抗生素安全性、有效性和适当剂量的文献，重点是莫西沙星。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/5f4cf7e84cd7/CRIOPM2021-5526097.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/047f56f4b5ff/CRIOPM2021-5526097.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/a2a2490452cf/CRIOPM2021-5526097.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/5f4cf7e84cd7/CRIOPM2021-5526097.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/047f56f4b5ff/CRIOPM2021-5526097.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/a2a2490452cf/CRIOPM2021-5526097.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ec/7943300/5f4cf7e84cd7/CRIOPM2021-5526097.003.jpg

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本文引用的文献

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Unilateral acute iris transillumination like syndrome following intracameral moxifloxacin injection.眼内注射莫西沙星后出现单侧急性虹膜光透射综合征。
Ocul Immunol Inflamm. 2022 Feb 17;30(2):318-319. doi: 10.1080/09273948.2020.1817495. Epub 2020 Sep 25.
2
Anterior Uveitis Due to Intracameral Moxifloxacin: A Case Report.前葡萄膜炎继发于眼内注射莫西沙星：病例报告。
Ocul Immunol Inflamm. 2021 Nov 17;29(7-8):1366-1369. doi: 10.1080/09273948.2020.1757120. Epub 2020 May 29.
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Unilateral acute iris depigmentation and transillumination after glaucoma surgery with mitomycin application and intracameral moxifloxacin.
Presumed atypical late-onset toxic anterior segment syndrome after implantable collamer lens implantation: a case report.
推测在可植入 Collamer 透镜植入术后发生非典型迟发性前节毒性综合征：病例报告。
BMC Ophthalmol. 2024 Aug 15;24(1):347. doi: 10.1186/s12886-024-03615-2.
4
Toxic anterior segment syndrome (TASS): A review and update.眼毒性前节综合征（TASS）：综述与更新。
Indian J Ophthalmol. 2024 Jan 1;72(1):11-18. doi: 10.4103/IJO.IJO_1796_23. Epub 2023 Dec 22.
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Frosted branch angiitis following corneal tear repair.角膜撕裂修复术后的霜样树枝状血管炎
Taiwan J Ophthalmol. 2022 Feb 14;12(4):491-494. doi: 10.4103/tjo.tjo_52_21. eCollection 2022 Oct-Dec.
青光眼手术联合应用丝裂霉素和前房内注射莫西沙星后出现的单侧急性虹膜色素脱失和透照缺损
Am J Ophthalmol Case Rep. 2020 Feb 27;18:100639. doi: 10.1016/j.ajoc.2020.100639. eCollection 2020 Jun.
4
Comparative corneal endothelial cell toxicity of differing intracameral moxifloxacin doses after phacoemulsification.白内障超声乳化术后不同前房内莫西沙星剂量的角膜内皮细胞毒性比较
J Cataract Refract Surg. 2020 Mar;46(3):355-359. doi: 10.1097/j.jcrs.0000000000000064.
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Can J Ophthalmol. 2019 Feb;54(1):33-39. doi: 10.1016/j.jcjo.2018.03.020. Epub 2018 May 21.
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J Cataract Refract Surg. 2019 Mar;45(3):343-350. doi: 10.1016/j.jcrs.2018.10.044. Epub 2019 Jan 25.