Uveitis and Ocular Immunology Department, Narayana Nethralaya, Bangalore.
Department of corneal and refractive surgery, Narayana Nethralaya, Bangalore..
Can J Ophthalmol. 2019 Feb;54(1):33-39. doi: 10.1016/j.jcjo.2018.03.020. Epub 2018 May 21.
To present clinical manifestations of bilateral acute depigmentation of Iris (BADI) and bilateral acute iris transillumination (BAIT) and discuss its pathogenesis.
Retrospective descriptive case study.
Twenty-two patients diagnosed with BADI or BAIT.
Case records of the above patients presented between May 2014 and November 2017 were retrospectively studied for history of present illness, clinical findings, and course of the disease.
Forty-one eyes of 22 patients were studied (17 cases of BADI and 5 cases of BAIT). Only 7 patients consumed oral fluoroquinolone (FQL), whereas 17 patients used topical FQL. Three patients did not use any FQL but did take ayurvedic medications. Seven patients had systemic viral prodrome, 12 had presumed viral conjunctivitis, and 3 had abundant sunlight exposure after FQL use (due to a road trip, sunbathing on a beach, and working as a traffic police officer). Three cases of BADI had unilateral depigmentation; 1 case of BAIT had iris transillumination only in one eye and a patch of depigmentation without transillumination in the other eye, akin to presentation of BADI. A PCR test for viral genome (HSV, VZV, CMV, and Rubella) revealed negative results in 2 cases of BADI and 3 cases of BAIT. Only 1 case of BADI had recurrence after 10 months.
Presentation of BADI and BAIT could be grossly asymmetric or unilateral. Clinical signs of BAIT and BADI can occur simultaneously in different eyes. The role of FQL in the pathogenesis of BADI and BAIT remains uncertain.
介绍双侧急性虹膜色素脱失（BADI）和双侧急性虹膜透光性（BAIT）的临床表现，并探讨其发病机制。
回顾性描述性病例研究。
22 例被诊断为 BADI 或 BAIT 的患者。
对 2014 年 5 月至 2017 年 11 月期间上述患者的病历进行回顾性研究，内容包括现病史、临床发现和疾病过程。
共研究了 22 例患者的 41 只眼（17 例 BADI，5 例 BAIT）。仅有 7 例患者口服氟喹诺酮（FQL），而 17 例患者局部使用 FQL。有 3 例患者未使用任何 FQL，但服用了阿育吠陀药物。7 例患者有全身病毒前驱症状，12 例患者有疑似病毒性结膜炎，3 例患者在使用 FQL 后暴露在大量阳光下（由于公路旅行、在海滩上晒太阳和当交通警察）。3 例 BADI 为单侧色素脱失；1 例 BAIT 仅一只眼虹膜透光性，另一只眼虹膜色素脱失但不透光，类似于 BADI 的表现。2 例 BADI 和 3 例 BAIT 的病毒基因组（HSV、VZV、CMV 和风疹）PCR 检测结果均为阴性。仅有 1 例 BADI 在 10 个月后复发。
BADI 和 BAIT 的表现可能严重不对称或单侧。BAIT 和 BADI 的临床体征可同时出现在不同的眼睛中。FQL 在 BADI 和 BAIT 发病机制中的作用尚不确定。
