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介电弹性体增强主动脉的可行性

Feasibility of a Dielectric Elastomer Augmented Aorta.

作者信息

Almanza Morgan, Clavica Francesco, Chavanne Jonathan, Moser David, Obrist Dominik, Carrel Thierry, Civet Yoan, Perriard Yves

机构信息

Integrated Actuators Laboratory École Polytechnique fédérale de Lausanne (EPFL) Neuchâtel 2000 Switzerland.

ARTORG Center for Biomedical Engineering Research University of Bern Bern 3012 Switzerland.

出版信息

Adv Sci (Weinh). 2021 Jan 25;8(6):2001974. doi: 10.1002/advs.202001974. eCollection 2021 Mar.

Abstract

Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric-elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. In vitro experiments using a pulsatile flow-loop, replicating human physiological flow and pressure conditions, show a reduction of 5.5% (47 mJ per cycle) of the heart energy with this device. Here, the controlled stiffness of the DEA graft, which is usually difficult to exploit for actuators, is perfectly matching the assistance principle. At the same time, the physiological aortic pressure is exploited to offer a prestretch to the DEA which otherwise would require an additional bulky pre-stretching system to reach high performances.

摘要

尽管心脏移植是治疗严重心力衰竭的金标准,但仍需要其他有效的治疗方法。一种介电弹性体主动脉被用于增强主动脉在人体循环系统中的生理作用。为此,作者开发了一种管状介电弹性体致动器(DEA),它能够通过在收缩期减轻主动脉的变形以及在舒张期增加其回弹力来辅助心脏。使用脉动流回路进行的体外实验,模拟人体生理流动和压力条件,结果表明使用该装置可使心脏能量减少5.5%(每周期47毫焦)。在此,DEA移植物的可控刚度(这通常很难用于致动器)与辅助原理完美匹配。同时,利用生理主动脉压力为DEA提供预拉伸,否则这将需要额外的庞大预拉伸系统才能达到高性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e98/7967089/6e18c0592dad/ADVS-8-2001974-g007.jpg

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