Lee Jungmin, Suh Heuy Sun, Hwang In Cheol
Department of Cognitive Science, University of California, Berkeley, CA, USA.
Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
Iran J Public Health. 2021 Feb;50(2):219-231. doi: 10.18502/ijph.v50i2.5334.
Age-related macular degeneration (AMD) and cardiovascular disease (CVD) share pathogenic mechanisms, and their lead-lag relationship remains unclear. We performed a meta-analysis of data from longitudinal studies to evaluate the interactive association between age-related macular degeneration (AMD) and cardiovascular disease (CVD).
A literature search was performed in PubMed, Embase, and Cochrane Library up to Feb 2019. Estimates were pooled by study quality and type of AMD and CVD. Publication bias was assessed by Begg's test.
We identified nine studies for the risk of AMD in CVD and ten studies for the risk of CVD in AMD. Overall, evidence for the risk of CVD in AMD patients was most robust. Both early and late AMD preceded CVD, but more solid significance existed in late AMD. Among the types of CVD, stroke was more tightly associated with AMD than coronary heart disease. Publication bias was not significant in either direction.
AMD is a risk factor for CVD, which is primarily driven by the increased risk of stroke in patients with late AMD. Moreover, these results suggested that AMD treatment and screening for CVD in AMD patients may have unexplored clinical benefits.
年龄相关性黄斑变性（AMD）与心血管疾病（CVD）具有共同的致病机制，它们之间的先后关系尚不清楚。我们对纵向研究的数据进行了荟萃分析，以评估年龄相关性黄斑变性（AMD）与心血管疾病（CVD）之间的交互关联。
截至2019年2月，在PubMed、Embase和Cochrane图书馆进行了文献检索。根据研究质量以及AMD和CVD的类型对估计值进行汇总。通过Begg检验评估发表偏倚。
我们确定了9项关于CVD患者发生AMD风险的研究和10项关于AMD患者发生CVD风险的研究。总体而言，AMD患者发生CVD风险的证据最为充分。早期和晚期AMD均先于CVD出现，但晚期AMD的相关性更显著。在CVD类型中，中风与AMD的关联比冠心病更为紧密。两个方向均不存在显著的发表偏倚。
AMD是CVD的一个危险因素，主要由晚期AMD患者中风风险增加所致。此外，这些结果表明，AMD治疗以及对AMD患者进行CVD筛查可能具有尚未被发掘的临床益处。
