Ghiani P, Uva B, Vallarino M, Mandich A, Masini M A
Institute of Comparative Anatomy, University of Genova, Italy.
Neurosci Lett. 1988 Feb 29;85(2):212-6. doi: 10.1016/0304-3940(88)90353-9.
In the subcommissural organ of male rats, a circumventricular organ situated inside the blood-brain barrier, specific receptors for angiotensin II were demonstrated by binding studies on homogenated membranes and by autoradiography carried out on frozen sections using 125I-angiotensin II. The receptor sites were localized in the subnuclear region of cells of the subcommissural organ. A single class of binding sites was found whose capacity was modulated by changes in the sodium plasma concentration which led to variations in plasma volume.
在雄性大鼠的联合下器官（一种位于血脑屏障内的室周器官）中，通过对匀浆膜进行结合研究以及使用¹²⁵I-血管紧张素II对冰冻切片进行放射自显影，证实了存在血管紧张素II的特异性受体。受体位点定位于联合下器官细胞的亚核区域。发现了一类单一的结合位点，其结合能力受血浆钠浓度变化的调节，而血浆钠浓度变化会导致血浆容量的改变。
